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• W1974804947 endingPage "270" @default.
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• W1974804947 abstract "A number of mathematical models have been used to describe percutaneous absorption kinetics. In general, most of these models have used either diffusion-based or compartmental equations. The object of any mathematical model is to a) be able to represent the processes associated with absorption accurately, b) be able to describe/summarize experimental data with parametric equations or moments, and c) predict kinetics under varying conditions. However, in describing the processes involved, some developed models often suffer from being of too complex a form to be practically useful. In this chapter, we attempt to approach the issue of mathematical modeling in percutaneous absorption from four perspectives. These are to a) describe simple practical models, b) provide an overview of the more complex models, c) summarize some of the more important/useful models used to date, and d) examine sonic practical applications of the models. The range of processes involved in percutaneous absorption and considered in developing the mathematical models in this chapter is shown in Fig. 1. We initially address in vitro skin diffusion models and consider a) constant donor concentration and receptor conditions, b) the corresponding flux, donor, skin, and receptor amount-time profiles for solutions, and c) amount- and flux-time profiles when the donor phase is removed. More complex issues, such as finite-volume donor phase, finite-volume receptor phase, the presence of an efflux. rate constant at the membrane-receptor interphase, and two-layer diffusion, are then considered. We then look at specific models and issues concerned with a) release from topical products, b) use of compartmental models as alternatives to diffusion models, c) concentration-dependent absorption, d) modeling of skin metabolism, e) role of solute-skin-vehicle interactions, f) effects of vehicle loss, a) shunt transport, and h) in vivo diffusion, compartmental, physiological, and deconvolution models. We conclude by examining topics such as a) deep tissue penetration, b) pharmacodynamics, c) iontophoresis, d) sonophoresis, and e) pitfalls in modeling." @default.
• W1974804947 created "2016-06-24" @default.
• W1974804947 creator A5002167014 @default.
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• W1974804947 date "2001-01-01" @default.
• W1974804947 modified "2023-10-18" @default.
• W1974804947 title "Mathematical models in percutaneous absorption" @default.
• W1974804947 cites W1549082581 @default.
• W1974804947 cites W1594382975 @default.
• W1974804947 cites W1599642775 @default.
• W1974804947 cites W161890079 @default.
• W1974804947 cites W1964472817 @default.
• W1974804947 cites W1966162377 @default.
• W1974804947 cites W1966339147 @default.
• W1974804947 cites W1968735486 @default.
• W1974804947 cites W1971554999 @default.
• W1974804947 cites W1973645528 @default.
• W1974804947 cites W1976617786 @default.
• W1974804947 cites W1976772348 @default.
• W1974804947 cites W1979744528 @default.
• W1974804947 cites W1982266831 @default.
• W1974804947 cites W1982715507 @default.
• W1974804947 cites W1986849672 @default.
• W1974804947 cites W198780892 @default.
• W1974804947 cites W1988137011 @default.
• W1974804947 cites W1993990283 @default.
• W1974804947 cites W1995564151 @default.
• W1974804947 cites W1996908687 @default.
• W1974804947 cites W1998840708 @default.
• W1974804947 cites W1998868591 @default.
• W1974804947 cites W1999610960 @default.
• W1974804947 cites W2003264270 @default.
• W1974804947 cites W2008284418 @default.
• W1974804947 cites W2008529728 @default.
• W1974804947 cites W2014551626 @default.
• W1974804947 cites W2015077793 @default.
• W1974804947 cites W2017628019 @default.
• W1974804947 cites W2018022746 @default.
• W1974804947 cites W2020952323 @default.
• W1974804947 cites W2023139243 @default.
• W1974804947 cites W2026173767 @default.
• W1974804947 cites W2030056063 @default.
• W1974804947 cites W2030763680 @default.
• W1974804947 cites W2032230446 @default.
• W1974804947 cites W2032390514 @default.
• W1974804947 cites W2033846755 @default.
• W1974804947 cites W2034222816 @default.
• W1974804947 cites W2035444687 @default.
• W1974804947 cites W2038860979 @default.
• W1974804947 cites W2038916844 @default.
• W1974804947 cites W2039318368 @default.
• W1974804947 cites W2040481579 @default.
• W1974804947 cites W2052342246 @default.
• W1974804947 cites W2052995310 @default.
• W1974804947 cites W2053158068 @default.
• W1974804947 cites W2059608198 @default.
• W1974804947 cites W2067653346 @default.
• W1974804947 cites W2067809768 @default.
• W1974804947 cites W2070814050 @default.
• W1974804947 cites W2071733437 @default.
• W1974804947 cites W2073413566 @default.
• W1974804947 cites W2080270121 @default.
• W1974804947 cites W2080423475 @default.
• W1974804947 cites W2097679483 @default.
• W1974804947 cites W2100232179 @default.
• W1974804947 cites W2100667289 @default.
• W1974804947 cites W2102200784 @default.
• W1974804947 cites W2107924267 @default.
• W1974804947 cites W2111804439 @default.
• W1974804947 cites W2121914308 @default.
• W1974804947 cites W2126014485 @default.
• W1974804947 cites W2143731124 @default.
• W1974804947 cites W2152548356 @default.
• W1974804947 cites W2314494482 @default.
• W1974804947 cites W2319161971 @default.
• W1974804947 cites W2326585121 @default.
• W1974804947 cites W2418901256 @default.
• W1974804947 cites W2775186493 @default.
• W1974804947 cites W300669465 @default.
• W1974804947 cites W346311905 @default.
• W1974804947 cites W62485863 @default.
• W1974804947 cites W70653800 @default.
• W1974804947 cites W75034512 @default.
• W1974804947 cites W2139975451 @default.
• W1974804947 doi "https://doi.org/10.1081/cus-120001859" @default.
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