FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974812912> ?p ?o ?g. }

• W1974812912 endingPage "107" @default.
• W1974812912 startingPage "97" @default.
• W1974812912 abstract "There is limited information available about the potential environmental effects of chloroquine (CQ), a widely used antimalarial agent and a promising inexpensive drug in the management of HIV disease. The acute effects of CQ were studied using four ecotoxicological model systems. The most sensitive bioindicator was the immobilization of the cladoceran Daphnia magna, with an EC50 of 12 μM CQ at 72 h and a non-observed adverse effect level of 2.5 μM CQ, followed very closely by the decrease of the uptake of neutral red and the reduction of the lysosomal function in the fish cell line PLHC-1 derived from the topminnow Poeciliopsis lucida, probably due to the selective accumulation of the drug into the lysosomes. There was significant cellular stress as indicated by the increases on metallothionein and glucose-6P dehydrogenase levels after 24 h of exposure and succinate dehydrogenase activity mainly after 48 h. No changes were observed for ethoxyresorufin-O-deethylase (EROD) activity. The least sensitive model was the inhibition of bioluminescence in the bacterium Vibrio fischeri. An increase of more than five-fold in the toxicity from 24 to 72 h of exposure was observed for the inhibition of the growth in the alga Chlorella vulgaris and the content of total protein and MTS tetrazolium salt metabolization in PLHC-1 cells. At the morphological level, the most evident alterations in PLHC-1 cultures were hydropic degeneration from 25 μM CQ after 24 h of exposure and the presence of many cells with pyknotic nuclei, condensed cytoplasm and apoptosis with concentrations higher than 50 μM CQ after 48 h of exposure. In conclusion, CQ should be classified as harmful to aquatic organisms." @default.
• W1974812912 created "2016-06-24" @default.
• W1974812912 creator A5005869824 @default.
• W1974812912 creator A5006916761 @default.
• W1974812912 creator A5025436915 @default.
• W1974812912 creator A5029021058 @default.
• W1974812912 creator A5053941542 @default.
• W1974812912 creator A5087238875 @default.
• W1974812912 date "2005-10-01" @default.
• W1974812912 modified "2023-10-07" @default.
• W1974812912 title "Ecotoxicological evaluation of the antimalarial drug chloroquine" @default.
• W1974812912 cites W1965040183 @default.
• W1974812912 cites W1966693911 @default.
• W1974812912 cites W1971138766 @default.
• W1974812912 cites W1978715187 @default.
• W1974812912 cites W1982449661 @default.
• W1974812912 cites W1990452038 @default.
• W1974812912 cites W1991461177 @default.
• W1974812912 cites W1997371510 @default.
• W1974812912 cites W1997518684 @default.
• W1974812912 cites W2001995619 @default.
• W1974812912 cites W2005458234 @default.
• W1974812912 cites W2005869512 @default.
• W1974812912 cites W2035297516 @default.
• W1974812912 cites W2042667414 @default.
• W1974812912 cites W2049259570 @default.
• W1974812912 cites W2060696438 @default.
• W1974812912 cites W2063103375 @default.
• W1974812912 cites W2065584348 @default.
• W1974812912 cites W2078841459 @default.
• W1974812912 cites W2082126125 @default.
• W1974812912 cites W2107521579 @default.
• W1974812912 cites W2145503666 @default.
• W1974812912 cites W2153227556 @default.
• W1974812912 cites W2156237697 @default.
• W1974812912 cites W2160530250 @default.
• W1974812912 cites W2163506845 @default.
• W1974812912 cites W2214671441 @default.
• W1974812912 doi "https://doi.org/10.1016/j.aquatox.2005.07.009" @default.
• W1974812912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16153718" @default.
• W1974812912 hasPublicationYear "2005" @default.
• W1974812912 type Work @default.
• W1974812912 sameAs 1974812912 @default.
• W1974812912 citedByCount "50" @default.
• W1974812912 countsByYear W19748129122013 @default.
• W1974812912 countsByYear W19748129122015 @default.
• W1974812912 countsByYear W19748129122016 @default.
• W1974812912 countsByYear W19748129122018 @default.
• W1974812912 countsByYear W19748129122019 @default.
• W1974812912 countsByYear W19748129122020 @default.
• W1974812912 countsByYear W19748129122021 @default.
• W1974812912 countsByYear W19748129122022 @default.
• W1974812912 countsByYear W19748129122023 @default.
• W1974812912 crossrefType "journal-article" @default.
• W1974812912 hasAuthorship W1974812912A5005869824 @default.
• W1974812912 hasAuthorship W1974812912A5006916761 @default.
• W1974812912 hasAuthorship W1974812912A5025436915 @default.
• W1974812912 hasAuthorship W1974812912A5029021058 @default.
• W1974812912 hasAuthorship W1974812912A5053941542 @default.
• W1974812912 hasAuthorship W1974812912A5087238875 @default.
• W1974812912 hasConcept C178790620 @default.
• W1974812912 hasConcept C185592680 @default.
• W1974812912 hasConcept C202751555 @default.
• W1974812912 hasConcept C203014093 @default.
• W1974812912 hasConcept C2777425658 @default.
• W1974812912 hasConcept C2778048844 @default.
• W1974812912 hasConcept C2780158794 @default.
• W1974812912 hasConcept C29730261 @default.
• W1974812912 hasConcept C55493867 @default.
• W1974812912 hasConcept C86803240 @default.
• W1974812912 hasConcept C96529984 @default.
• W1974812912 hasConcept C98274493 @default.
• W1974812912 hasConceptScore W1974812912C178790620 @default.
• W1974812912 hasConceptScore W1974812912C185592680 @default.
• W1974812912 hasConceptScore W1974812912C202751555 @default.
• W1974812912 hasConceptScore W1974812912C203014093 @default.
• W1974812912 hasConceptScore W1974812912C2777425658 @default.
• W1974812912 hasConceptScore W1974812912C2778048844 @default.
• W1974812912 hasConceptScore W1974812912C2780158794 @default.
• W1974812912 hasConceptScore W1974812912C29730261 @default.
• W1974812912 hasConceptScore W1974812912C55493867 @default.
• W1974812912 hasConceptScore W1974812912C86803240 @default.
• W1974812912 hasConceptScore W1974812912C96529984 @default.
• W1974812912 hasConceptScore W1974812912C98274493 @default.
• W1974812912 hasFunder F4320321764 @default.
• W1974812912 hasFunder F4320323573 @default.
• W1974812912 hasIssue "2" @default.
• W1974812912 hasLocation W19748129121 @default.
• W1974812912 hasLocation W19748129122 @default.
• W1974812912 hasOpenAccess W1974812912 @default.
• W1974812912 hasPrimaryLocation W19748129121 @default.
• W1974812912 hasRelatedWork W1978279325 @default.
• W1974812912 hasRelatedWork W1992980093 @default.
• W1974812912 hasRelatedWork W2055319292 @default.
• W1974812912 hasRelatedWork W2063571681 @default.
• W1974812912 hasRelatedWork W2078483215 @default.
• W1974812912 hasRelatedWork W2367600771 @default.
• W1974812912 hasRelatedWork W2388774808 @default.

• next