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- W1974813019 abstract "Innovative treatment strategies are needed for women with metastatic breast cancer. In a phase I immunotherapy (IT) trial, infusions of ATC armed with anti-CD3 x anti-Her2/neu bispecific antibody (Her2Bi) induced specific cytotoxicity (SC) in the peripheral blood lymphocytes (PBL) directed at SK-BR-3 breast cancer cells. Armed ATC induced high levels of Th1 cytokines and IL-12 in the serum of patients. After IT, we obtained memory T cells by leukopheresis, expanded the T cells, and re-infused the T cells after PBSCT to test the hypothesis that the transfer of immuneT cells would reconstitute anti-tumor activity after PBSCT." @default.
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- W1974813019 date "2010-02-01" @default.
- W1974813019 modified "2023-10-17" @default.
- W1974813019 title "Primed And Boosted Anti-Breast Cancer Tumor Immunity After Autologous Peripheral Blood Stem Cell Transplant (PBSCT): In Vivo Priming With T Cells Armed With Anti-CD3 X anti-Her2/neu Bispecific Antibody (Her2Bi) Pre PBSCT And Boosting After PBSCT With Activated T Cells (ATC)" @default.
- W1974813019 doi "https://doi.org/10.1016/j.bbmt.2009.12.044" @default.
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