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• W1974814769 abstract "p-Coumaric and ferulic acid are actively taken up by monocarboxylic acid transporter (MCT), whereas gallic acid, caffeic acid (CA), and rosmarinic acid (RA) are absorbed by paracellular diffusion in human intestinal Caco-2 cells, although CA has low affinity for MCT. We previously demonstrated that p-coumaric acid has a much higher absorption efficiency than gallic acid in rats, owing to the MCT-mediated absorption of p-coumaric acid in vivo (J. Agric. Food Chem. 2004, 52, 2527−2532). Here, absorption of orally administered CA and RA in rats has been studied to investigate their intestinal absorption characteristics and pharmacokinetics in vivo and to compare the results with those of p-coumaric and gallic acids obtained under identical conditions. Rats were given 100 μmol/kg body weight of CA and RA, and blood was collected from the portal vein and abdominal artery after administration. CA, RA, and their metabolites were quantified by a coulometric detection method using HPLC−ECD. The serum concentration of intact CA and RA in the portal vein peaked at 10 min after administration, with a Cmax of 11.24 μmol/L for CA and 1.36 μmol/L for RA. The area under the curve (AUC) for intact CA and RA in the portal vein was calculated from the serum concentration−time profile to be 585.0 and 60.4 μmol min L-1, respectively. The absorption efficiency of CA was about 9.7-fold higher than that of RA. Overall, the absorption efficiency of these compounds in vivo increases in the order: gallic acid = RA < CA < p-coumaric acid, which is in good agreement with results obtained in Caco-2 cells in vitro. Keywords: Caffeic acid; rosmarinic acid; monocarboxylic acid transporter; intestinal absorption; rats" @default.
• W1974814769 created "2016-06-24" @default.
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• W1974814769 date "2005-05-12" @default.
• W1974814769 modified "2023-10-15" @default.
• W1974814769 title "Pharmacokinetic Study of Caffeic and Rosmarinic Acids in Rats after Oral Administration" @default.
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• W1974814769 doi "https://doi.org/10.1021/jf0478307" @default.
• W1974814769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15941309" @default.
• W1974814769 hasPublicationYear "2005" @default.
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