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• W1974840445 abstract "Herpetomonas muscarum muscarum is a flagellate parasite of the family Trypanosomatidae, whose cell differentiation can be triggered by the lipid mediator, PAF. In this study we demonstrate for the first time that PAF effect relies on the activation of casein kinase 2 (CK2). The classical antagonist of PAF receptor, WEB 2086, abrogated PAF-enhanced CK2 activity. CK2 activation by PAF was also inhibited when parasite extracts were assayed in the presence of modulators of PKC, MAPK, and both Ser/Thr and Tyr phosphatases. Finally, a cell permeable inhibitor of CK2 (DRB) suppressed PAF-induced cell differentiation in a dose-dependent manner." @default.
• W1974840445 created "2016-06-24" @default.
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• W1974840445 date "2002-05-01" @default.
• W1974840445 modified "2023-09-26" @default.
• W1974840445 title "Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum" @default.
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• W1974840445 doi "https://doi.org/10.1016/s0006-291x(02)00395-9" @default.
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