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- W1974851569 abstract "Immature dendritic cells (imDCs) are increasingly viewed as mediators of T-cell tolerance. We investigated factors enabling induction of regulatory T (Treg) cells through syngeneic imDC/mesenchymal stem cell (MSC) co-cultures in vitro and immunosuppressive effects of MSC-mediated imDCs (MSCs were excluded after 72 h co-culture) in vivo. In these experiments, we found that Foxp3(+) Treg cell population remarkably increased after the T cell priming phase when splenocytes were co-cultured with both imDCs and MSCs, presumably inducing naive T cells into Treg cells by MSCs and imDCs. In parallel, TGF-β secretion was markedly induced from the imDC+MSC+splenocyte culture supernatant to a significant level at 72-h co-culture, compared to the MSC or imDC+splenocyte co-culture. Based on these results, using a murine melanoma tumor model, we confirmed that the subcutaneous injection of B16 cells induced a perfect tumor incidence in allogeneic recipients when MSC-mediated DCs were coinjected. Consequently, these results suggested that immune tolerance with MSC-mediated DCs leads to immunosuppression induced by at least Foxp3-specific Treg cells. This tool may be useful in clinical trials due to the yet unknown side effects of stem cell therapy." @default.
- W1974851569 created "2016-06-24" @default.
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- W1974851569 date "2010-11-01" @default.
- W1974851569 modified "2023-09-25" @default.
- W1974851569 title "Mesenchymal stem cell-mediated immature dendritic cells induce regulatory T cell-based immunosuppressive effect" @default.
- W1974851569 doi "https://doi.org/10.1016/j.jbiotec.2010.09.594" @default.
- W1974851569 hasPublicationYear "2010" @default.
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