FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974857224> ?p ?o ?g. }

• W1974857224 endingPage "799" @default.
• W1974857224 startingPage "792" @default.
• W1974857224 abstract "Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets. Although the endothelium is recognized to play critical roles in focal vascular sclerosis, the contributions of valvular endothelial phenotypes to aortic valve sclerosis and side-specific susceptibility to calcification are poorly understood. Using RNA amplification and cDNA microarrays, we identified 584 genes as differentially expressed in situ by the endothelium on the aortic side versus ventricular side of normal adult pig aortic valves. These differential transcriptional profiles, representative of the steady state in vivo, identify globally distinct endothelial phenotypes on opposite sides of the aortic valve. Several over-represented biological classifications with putative relevance to endothelial regulation of valvular homeostasis and aortic-side vulnerability to calcification were identified among the differentially expressed genes. Of note, multiple inhibitors of cardiovascular calcification were significantly less expressed by endothelium on the disease-prone aortic side of the valve, suggesting side-specific permissiveness to calcification. However, coexisting putative protective mechanisms were also expressed. Specifically, enhanced antioxidative gene expression and the lack of differential expression of proinflammatory molecules on the aortic side may protect against inflammation and lesion initiation in the normal valve. These data implicate the endothelium in regulating valvular calcification and suggest that spatial heterogeneity of valvular endothelial phenotypes may contribute to the focal susceptibility for lesion development." @default.
• W1974857224 created "2016-06-24" @default.
• W1974857224 creator A5012747435 @default.
• W1974857224 creator A5029828135 @default.
• W1974857224 creator A5044878468 @default.
• W1974857224 creator A5058923571 @default.
• W1974857224 date "2005-04-15" @default.
• W1974857224 modified "2023-10-14" @default.
• W1974857224 title "Spatial Heterogeneity of Endothelial Phenotypes Correlates With Side-Specific Vulnerability to Calcification in Normal Porcine Aortic Valves" @default.
• W1974857224 cites W1211851132 @default.
• W1974857224 cites W1503749567 @default.
• W1974857224 cites W1510237891 @default.
• W1974857224 cites W172089148 @default.
• W1974857224 cites W1940673168 @default.
• W1974857224 cites W1965772617 @default.
• W1974857224 cites W1974287326 @default.
• W1974857224 cites W1975529354 @default.
• W1974857224 cites W1979617511 @default.
• W1974857224 cites W2000647744 @default.
• W1974857224 cites W2020211786 @default.
• W1974857224 cites W2020331803 @default.
• W1974857224 cites W2021193475 @default.
• W1974857224 cites W2022126825 @default.
• W1974857224 cites W2025019677 @default.
• W1974857224 cites W2028062768 @default.
• W1974857224 cites W2038659379 @default.
• W1974857224 cites W2039017944 @default.
• W1974857224 cites W2039182800 @default.
• W1974857224 cites W2058579856 @default.
• W1974857224 cites W2059571803 @default.
• W1974857224 cites W2070818357 @default.
• W1974857224 cites W2074206215 @default.
• W1974857224 cites W2077744249 @default.
• W1974857224 cites W2081291016 @default.
• W1974857224 cites W2091574626 @default.
• W1974857224 cites W2103502313 @default.
• W1974857224 cites W2104974378 @default.
• W1974857224 cites W2106971003 @default.
• W1974857224 cites W2111504832 @default.
• W1974857224 cites W2115128893 @default.
• W1974857224 cites W2115676371 @default.
• W1974857224 cites W2118999235 @default.
• W1974857224 cites W2121777852 @default.
• W1974857224 cites W2122199417 @default.
• W1974857224 cites W2127938920 @default.
• W1974857224 cites W2129503078 @default.
• W1974857224 cites W2129651548 @default.
• W1974857224 cites W2130149021 @default.
• W1974857224 cites W2147834547 @default.
• W1974857224 cites W2148660920 @default.
• W1974857224 cites W2154833555 @default.
• W1974857224 cites W2155939240 @default.
• W1974857224 cites W2159776277 @default.
• W1974857224 cites W2163408805 @default.
• W1974857224 cites W2163547289 @default.
• W1974857224 cites W2164591127 @default.
• W1974857224 cites W2166249898 @default.
• W1974857224 cites W2167743750 @default.
• W1974857224 cites W2320913451 @default.
• W1974857224 cites W66976633 @default.
• W1974857224 doi "https://doi.org/10.1161/01.res.0000161998.92009.64" @default.
• W1974857224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3057118" @default.
• W1974857224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15761200" @default.
• W1974857224 hasPublicationYear "2005" @default.
• W1974857224 type Work @default.
• W1974857224 sameAs 1974857224 @default.
• W1974857224 citedByCount "249" @default.
• W1974857224 countsByYear W19748572242012 @default.
• W1974857224 countsByYear W19748572242013 @default.
• W1974857224 countsByYear W19748572242014 @default.
• W1974857224 countsByYear W19748572242015 @default.
• W1974857224 countsByYear W19748572242016 @default.
• W1974857224 countsByYear W19748572242017 @default.
• W1974857224 countsByYear W19748572242018 @default.
• W1974857224 countsByYear W19748572242019 @default.
• W1974857224 countsByYear W19748572242020 @default.
• W1974857224 countsByYear W19748572242021 @default.
• W1974857224 countsByYear W19748572242022 @default.
• W1974857224 countsByYear W19748572242023 @default.
• W1974857224 crossrefType "journal-article" @default.
• W1974857224 hasAuthorship W1974857224A5012747435 @default.
• W1974857224 hasAuthorship W1974857224A5029828135 @default.
• W1974857224 hasAuthorship W1974857224A5044878468 @default.
• W1974857224 hasAuthorship W1974857224A5058923571 @default.
• W1974857224 hasBestOaLocation W19748572241 @default.
• W1974857224 hasConcept C104317684 @default.
• W1974857224 hasConcept C126322002 @default.
• W1974857224 hasConcept C127716648 @default.
• W1974857224 hasConcept C142724271 @default.
• W1974857224 hasConcept C2776992346 @default.
• W1974857224 hasConcept C2780309369 @default.
• W1974857224 hasConcept C2780714102 @default.
• W1974857224 hasConcept C2781156865 @default.
• W1974857224 hasConcept C54355233 @default.
• W1974857224 hasConcept C71924100 @default.
• W1974857224 hasConcept C86803240 @default.
• W1974857224 hasConceptScore W1974857224C104317684 @default.
• W1974857224 hasConceptScore W1974857224C126322002 @default.

• next