FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974865168> ?p ?o ?g. }

• W1974865168 endingPage "20" @default.
• W1974865168 startingPage "9" @default.
• W1974865168 abstract "Sequential interpenetrating network (IPN) of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were prepared and crosslinked with glutaraldehyde (GA) to form pH-sensitive microspheres by the water-in-oil (w/o) emulsification method. Microspheres were used to deliver a model anti-inflammatory drug, diclofenac sodium (DS), to the intestine. The formed IPN was analyzed by Fourier transform infrared spectroscopy (FTIR). Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses were done on the drug-loaded microspheres to confirm the polymorphism of DS. Results indicated a molecular level dispersion of DS in the IPN. Microspheres formed were spherical with the smooth surfaces as evidenced by scanning electron microscopy (SEM). Particle size and size distribution was studied using laser light diffraction particle size analyzer. Particle size analysis was also done by optical microscope for the selected microspheres; the change in diameter of the microspheres when soaked in different media at different time intervals was measured by optical microscope. Microspheres showed a pulsatile swelling behavior when the pH of the swelling media was changed. The swelling data were fitted to an empirical equation to understand the phenomenon of water transport as well as to calculate the diffusion coefficient (D). Values of D in acidic media were lower than those found in basic media. The values of D decrease with increasing crosslinking of the matrix. In-vitro release studies have been performed in 1.2 and 7.4 pH media to simulate gastric and intestinal conditions. The results indicated a dependence on the pH of the release media, extent of crosslinking and the amount of drug loading." @default.
• W1974865168 created "2016-06-24" @default.
• W1974865168 creator A5016350367 @default.
• W1974865168 creator A5076026149 @default.
• W1974865168 date "2004-04-01" @default.
• W1974865168 modified "2023-10-17" @default.
• W1974865168 title "Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine" @default.
• W1974865168 cites W1604690433 @default.
• W1974865168 cites W1949065896 @default.
• W1974865168 cites W1963481363 @default.
• W1974865168 cites W1966498750 @default.
• W1974865168 cites W1966934689 @default.
• W1974865168 cites W1968764590 @default.
• W1974865168 cites W1971043656 @default.
• W1974865168 cites W1977993705 @default.
• W1974865168 cites W1986528315 @default.
• W1974865168 cites W2000864034 @default.
• W1974865168 cites W2007416715 @default.
• W1974865168 cites W2023603664 @default.
• W1974865168 cites W2023989058 @default.
• W1974865168 cites W2032104010 @default.
• W1974865168 cites W2033952243 @default.
• W1974865168 cites W2041297006 @default.
• W1974865168 cites W2042468204 @default.
• W1974865168 cites W2061694075 @default.
• W1974865168 cites W2063385639 @default.
• W1974865168 cites W2094461852 @default.
• W1974865168 cites W2153069696 @default.
• W1974865168 doi "https://doi.org/10.1016/j.jconrel.2003.12.025" @default.
• W1974865168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15063025" @default.
• W1974865168 hasPublicationYear "2004" @default.
• W1974865168 type Work @default.
• W1974865168 sameAs 1974865168 @default.
• W1974865168 citedByCount "194" @default.
• W1974865168 countsByYear W19748651682012 @default.
• W1974865168 countsByYear W19748651682013 @default.
• W1974865168 countsByYear W19748651682014 @default.
• W1974865168 countsByYear W19748651682015 @default.
• W1974865168 countsByYear W19748651682016 @default.
• W1974865168 countsByYear W19748651682017 @default.
• W1974865168 countsByYear W19748651682018 @default.
• W1974865168 countsByYear W19748651682019 @default.
• W1974865168 countsByYear W19748651682020 @default.
• W1974865168 countsByYear W19748651682021 @default.
• W1974865168 countsByYear W19748651682022 @default.
• W1974865168 countsByYear W19748651682023 @default.
• W1974865168 crossrefType "journal-article" @default.
• W1974865168 hasAuthorship W1974865168A5016350367 @default.
• W1974865168 hasAuthorship W1974865168A5076026149 @default.
• W1974865168 hasConcept C121332964 @default.
• W1974865168 hasConcept C127413603 @default.
• W1974865168 hasConcept C13965031 @default.
• W1974865168 hasConcept C15920480 @default.
• W1974865168 hasConcept C159985019 @default.
• W1974865168 hasConcept C160892712 @default.
• W1974865168 hasConcept C185592680 @default.
• W1974865168 hasConcept C187530423 @default.
• W1974865168 hasConcept C188027245 @default.
• W1974865168 hasConcept C192562407 @default.
• W1974865168 hasConcept C26771246 @default.
• W1974865168 hasConcept C2777529624 @default.
• W1974865168 hasConcept C2778540859 @default.
• W1974865168 hasConcept C2780503075 @default.
• W1974865168 hasConcept C2780666587 @default.
• W1974865168 hasConcept C2908765736 @default.
• W1974865168 hasConcept C39519442 @default.
• W1974865168 hasConcept C42360764 @default.
• W1974865168 hasConcept C43617362 @default.
• W1974865168 hasConcept C521977710 @default.
• W1974865168 hasConcept C97355855 @default.
• W1974865168 hasConceptScore W1974865168C121332964 @default.
• W1974865168 hasConceptScore W1974865168C127413603 @default.
• W1974865168 hasConceptScore W1974865168C13965031 @default.
• W1974865168 hasConceptScore W1974865168C15920480 @default.
• W1974865168 hasConceptScore W1974865168C159985019 @default.
• W1974865168 hasConceptScore W1974865168C160892712 @default.
• W1974865168 hasConceptScore W1974865168C185592680 @default.
• W1974865168 hasConceptScore W1974865168C187530423 @default.
• W1974865168 hasConceptScore W1974865168C188027245 @default.
• W1974865168 hasConceptScore W1974865168C192562407 @default.
• W1974865168 hasConceptScore W1974865168C26771246 @default.
• W1974865168 hasConceptScore W1974865168C2777529624 @default.
• W1974865168 hasConceptScore W1974865168C2778540859 @default.
• W1974865168 hasConceptScore W1974865168C2780503075 @default.
• W1974865168 hasConceptScore W1974865168C2780666587 @default.
• W1974865168 hasConceptScore W1974865168C2908765736 @default.
• W1974865168 hasConceptScore W1974865168C39519442 @default.
• W1974865168 hasConceptScore W1974865168C42360764 @default.
• W1974865168 hasConceptScore W1974865168C43617362 @default.
• W1974865168 hasConceptScore W1974865168C521977710 @default.
• W1974865168 hasConceptScore W1974865168C97355855 @default.
• W1974865168 hasIssue "1" @default.
• W1974865168 hasLocation W19748651681 @default.
• W1974865168 hasLocation W19748651682 @default.
• W1974865168 hasOpenAccess W1974865168 @default.
• W1974865168 hasPrimaryLocation W19748651681 @default.
• W1974865168 hasRelatedWork W1535792550 @default.
• W1974865168 hasRelatedWork W1974865168 @default.

• next