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- W1974872156 abstract "Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome. Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome." @default.
- W1974872156 created "2016-06-24" @default.
- W1974872156 creator A5019907039 @default.
- W1974872156 creator A5038297278 @default.
- W1974872156 creator A5090701034 @default.
- W1974872156 date "2005-12-01" @default.
- W1974872156 modified "2023-10-15" @default.
- W1974872156 title "An emerging role for PtdIns(4,5)P2-mediated signalling in human disease" @default.
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- W1974872156 doi "https://doi.org/10.1016/j.tips.2005.10.004" @default.
- W1974872156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16253350" @default.
- W1974872156 hasPublicationYear "2005" @default.
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