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- W1974879905 abstract "<b><i>Objective:</i></b> Given the magnitude of the HIV epidemic infection, many viral and human factors were analyzed, and the most decisive was the variant CCR5-Δ32. The presence of a low HIV prevalence (1.8%) in Gabon in the 1990s, compared to neighboring countries, represents a paradox that led us to search for viral and human genetic variants in this country. In this study, only variants of coreceptors and chemokines were investigated. <b><i>Methods:</i></b> Variants of the coding region of the CCR5 gene were analyzed by denaturing gradient gel electrophoresis, and then variants of SDF1 and CCR2b were determined by polymerase chain reaction-restriction fragment length polymorphism. <b><i>Results:</i></b> Four rare variants of the CCR5 coreceptor were found, while CCR5-Δ32 and CCR5m303 variants were not found. No association with CCR2b-V64I (17%) and SDF1-3′A (2%) variants was determined in relation to HIV-1 infection in Gabonese patients. <b><i>Conclusion:</i></b> The paradox of HIV seroprevalence in Gabon, which ended in the 2000s, was not caused by human genetic variants but rather by environmental factors." @default.
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- W1974879905 date "2015-01-01" @default.
- W1974879905 modified "2023-10-16" @default.
- W1974879905 title "Genotyping of CCR5 Gene, CCR2b and SDF1 Variants Related to HIV-1 Infection in Gabonese Subjects" @default.
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- W1974879905 doi "https://doi.org/10.1159/000369016" @default.
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