FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974886898> ?p ?o ?g. }

• W1974886898 endingPage "63" @default.
• W1974886898 startingPage "52" @default.
• W1974886898 abstract "Little is known about follicle-stimulating hormone (FSH) function during oocyte growth in fishes. The goal of this study was to gain a fundamental understanding of FSH action on ovarian follicles during early secondary oocyte growth by examining changes in ovarian gene expression and steroidogenesis in response to FSH. Coho salmon (Oncorhynchus kisutch) mid to late cortical alveolus stage follicles were incubated with or without salmon FSH in time-course and concentration–response experiments. Steroid levels were determined in the culture medium by immunoassay and levels of target ovarian mRNAs were determined by quantitative RT-PCR. Medium estradiol-17β (E2) levels increased in response to FSH and plateaued by 36 h, while testosterone levels increased similarly but were lower and more variable than E2. Gonadotropin receptor transcripts were differentially regulated, with fshr and lhcgr being down- and up- regulated, respectively. Transcripts encoding proteins involved in steroidogenesis, such as star and hsd3b were significantly upregulated by FSH, whereas aromatase (cyp19a1a) mRNA was unaffected by FSH and declined over time in culture. A recently identified teleost gene, bmp16, was suppressed by FSH and an anti-apoptotic factor, clusterin 1 (clu1), was upregulated by FSH. Lesser FSH effects were observed on igf2, cyp11a1 and cyp17a1, which were stimulated, and igf1ra, inhbb, amh and apoe, which were suppressed. As evident by the significant increases in steroid production and transcripts for specific steroidogenesis-related proteins, FSH influences steroidogenesis during early secondary growth and may be a critical signal for puberty onset. Effects of FSH on ovarian anti-apoptotic and growth factor genes suggest roles for FSH in cell survival, growth and differentiation in teleosts." @default.
• W1974886898 created "2016-06-24" @default.
• W1974886898 creator A5006029068 @default.
• W1974886898 creator A5012071594 @default.
• W1974886898 creator A5051951935 @default.
• W1974886898 date "2011-03-01" @default.
• W1974886898 modified "2023-10-18" @default.
• W1974886898 title "Follicle-stimulating hormone regulation of ovarian transcripts for steroidogenesis-related proteins and cell survival, growth and differentiation factors in vitro during early secondary oocyte growth in coho salmon" @default.
• W1974886898 cites W1480678547 @default.
• W1974886898 cites W1560402984 @default.
• W1974886898 cites W172343325 @default.
• W1974886898 cites W1968409042 @default.
• W1974886898 cites W1972785483 @default.
• W1974886898 cites W1976955422 @default.
• W1974886898 cites W1979394752 @default.
• W1974886898 cites W1984059085 @default.
• W1974886898 cites W1985857703 @default.
• W1974886898 cites W1987993545 @default.
• W1974886898 cites W1989279004 @default.
• W1974886898 cites W1991648044 @default.
• W1974886898 cites W1992051212 @default.
• W1974886898 cites W1992628457 @default.
• W1974886898 cites W1994459287 @default.
• W1974886898 cites W2012158660 @default.
• W1974886898 cites W2020565916 @default.
• W1974886898 cites W2020632264 @default.
• W1974886898 cites W2021560293 @default.
• W1974886898 cites W2026553604 @default.
• W1974886898 cites W2028604250 @default.
• W1974886898 cites W2032926727 @default.
• W1974886898 cites W2034484204 @default.
• W1974886898 cites W2036670613 @default.
• W1974886898 cites W2037880763 @default.
• W1974886898 cites W2040660061 @default.
• W1974886898 cites W2041564874 @default.
• W1974886898 cites W2043001385 @default.
• W1974886898 cites W2051039257 @default.
• W1974886898 cites W2054804693 @default.
• W1974886898 cites W2057336811 @default.
• W1974886898 cites W2059220801 @default.
• W1974886898 cites W2060707600 @default.
• W1974886898 cites W2061930043 @default.
• W1974886898 cites W2065123066 @default.
• W1974886898 cites W2066376058 @default.
• W1974886898 cites W2067098905 @default.
• W1974886898 cites W2075535204 @default.
• W1974886898 cites W2076340639 @default.
• W1974886898 cites W2078135866 @default.
• W1974886898 cites W2078207743 @default.
• W1974886898 cites W2078602147 @default.
• W1974886898 cites W2078903341 @default.
• W1974886898 cites W2079505915 @default.
• W1974886898 cites W2080436446 @default.
• W1974886898 cites W2087941800 @default.
• W1974886898 cites W2091771658 @default.
• W1974886898 cites W2094682330 @default.
• W1974886898 cites W2095915766 @default.
• W1974886898 cites W2098586878 @default.
• W1974886898 cites W2099854428 @default.
• W1974886898 cites W2101436005 @default.
• W1974886898 cites W2102859380 @default.
• W1974886898 cites W2118506472 @default.
• W1974886898 cites W2119265611 @default.
• W1974886898 cites W2124080367 @default.
• W1974886898 cites W2126516708 @default.
• W1974886898 cites W2132064124 @default.
• W1974886898 cites W2133045719 @default.
• W1974886898 cites W2138112162 @default.
• W1974886898 cites W2138700889 @default.
• W1974886898 cites W2144272510 @default.
• W1974886898 cites W2151364325 @default.
• W1974886898 cites W2156634674 @default.
• W1974886898 cites W2161255361 @default.
• W1974886898 cites W2168075403 @default.
• W1974886898 cites W4237536168 @default.
• W1974886898 cites W4245001879 @default.
• W1974886898 cites W4247639014 @default.
• W1974886898 cites W4256303336 @default.
• W1974886898 doi "https://doi.org/10.1016/j.ygcen.2010.12.016" @default.
• W1974886898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21187099" @default.
• W1974886898 hasPublicationYear "2011" @default.
• W1974886898 type Work @default.
• W1974886898 sameAs 1974886898 @default.
• W1974886898 citedByCount "74" @default.
• W1974886898 countsByYear W19748868982012 @default.
• W1974886898 countsByYear W19748868982013 @default.
• W1974886898 countsByYear W19748868982014 @default.
• W1974886898 countsByYear W19748868982015 @default.
• W1974886898 countsByYear W19748868982016 @default.
• W1974886898 countsByYear W19748868982017 @default.
• W1974886898 countsByYear W19748868982018 @default.
• W1974886898 countsByYear W19748868982019 @default.
• W1974886898 countsByYear W19748868982020 @default.
• W1974886898 countsByYear W19748868982021 @default.
• W1974886898 countsByYear W19748868982022 @default.
• W1974886898 countsByYear W19748868982023 @default.
• W1974886898 crossrefType "journal-article" @default.
• W1974886898 hasAuthorship W1974886898A5006029068 @default.

• next