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• W1974889077 abstract "Melanoma is resistant to cytotoxic therapy, and treatment options for advanced disease have been limited historically. However, improved understanding of melanoma driver mutations, particularly those involving the mitogen-activated protein kinase pathway, has led to the development of targeted therapies that are effective in this previously treatment-refractory disease. In cutaneous melanomas with BRAF V600 mutations the selective RAF inhibitors, vemurafenib and dabrafenib, and the MEK inhibitor, trametinib, have demonstrated survival benefits. Early signals of efficacy have also been demonstrated with MEK inhibitors in melanomas with NRAS mutations, and KIT inhibitors offer promise in melanomas driven through activation of their target receptor." @default.
• W1974889077 created "2016-06-24" @default.
• W1974889077 creator A5020515172 @default.
• W1974889077 creator A5031105664 @default.
• W1974889077 date "2014-06-01" @default.
• W1974889077 modified "2023-10-14" @default.
• W1974889077 title "Targeted Therapies for Cutaneous Melanoma" @default.
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• W1974889077 doi "https://doi.org/10.1016/j.hoc.2014.02.003" @default.
• W1974889077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24880943" @default.
• W1974889077 hasPublicationYear "2014" @default.
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