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- W1974889178 abstract "Synchronous Chinese hamster ovary cells were heated in G1 and incubated at 37 degrees C at pH 6.75 or pH 7.4 before they were heated a second time. The magnitude and rate of development and decay of thermotolerance were greatly reduced at pH 6.75. This was also observed for asynchronous cells. Furthermore, the heat-induced delay in cell cycle progression was greatly enhanced at low pH and correlated with the reduced rate for development and decay of thermotolerance. However, studies with [3H]TdR to kill cells entering S phase showed that the decay of thermotolerance is relatively independent of the cell cycle. Therefore, low pH apparently slows many cell processes, including those associated with heat-induced cell cycle delay and the rate of development and decay of thermotolerance." @default.
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- W1974889178 date "1986-04-01" @default.
- W1974889178 modified "2023-09-24" @default.
- W1974889178 title "Effect of pH and Cell Cycle Progression on Development and Decay of Thermotolerance" @default.
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- W1974889178 doi "https://doi.org/10.2307/3576566" @default.
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