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• W1974890932 abstract "d-penicillamine is effectively used in the lifelong treatment of copper toxicosis in Bedlington terriers and Wilson’s disease in humans. A complex form of copper-associated hepatitis has recently been characterized in the Labrador retriever. The aims of this study were to evaluate the effectiveness of d-penicillamine treatment for copper-associated hepatitis in this breed, to study the effects on hepatic copper, iron and zinc concentrations, and to evaluate parameters to predict optimal duration of treatment. Forty-three client owned Labrador retrievers that were diagnosed with increased hepatic copper were treated with d-penicillamine and underwent at least one follow-up examination including a liver biopsy for histopathological scoring of inflammatory lesions. Hepatic copper, iron and zinc concentrations were determined in the initial and follow-up biopsies by instrumental neutron activation analysis. The influence of initial hepatic copper concentration, sex, age, d-penicillamine formulation and the occurrence of side effects were investigated for their influence on hepatic copper concentration after a certain period of treatment by generalized mixed modelling. d-penicillamine proved to be effective in reducing hepatic copper concentration and associated inflammatory lesions. Parameters derived from the model can be used to estimate the necessary duration of d-penicillamine treatment for Labrador retrievers with increased hepatic copper concentration. Continuous, lifelong d-penicillamine treatment is not recommended in this breed, as there may be a risk for hepatic copper and zinc deficiency." @default.
• W1974890932 created "2016-06-24" @default.
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• W1974890932 date "2013-06-01" @default.
• W1974890932 modified "2023-10-15" @default.
• W1974890932 title "d-penicillamine treatment of copper-associated hepatitis in Labrador retrievers" @default.
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• W1974890932 doi "https://doi.org/10.1016/j.tvjl.2012.12.013" @default.
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