Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974892433> ?p ?o ?g. }
- W1974892433 endingPage "522" @default.
- W1974892433 startingPage "517" @default.
- W1974892433 abstract "Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death." @default.
- W1974892433 created "2016-06-24" @default.
- W1974892433 creator A5038788451 @default.
- W1974892433 creator A5048952884 @default.
- W1974892433 creator A5057714274 @default.
- W1974892433 creator A5081859501 @default.
- W1974892433 creator A5082376747 @default.
- W1974892433 date "2011-08-31" @default.
- W1974892433 modified "2023-10-14" @default.
- W1974892433 title "Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death" @default.
- W1974892433 cites W1968064237 @default.
- W1974892433 cites W1970565325 @default.
- W1974892433 cites W1973477211 @default.
- W1974892433 cites W1986996580 @default.
- W1974892433 cites W1995025616 @default.
- W1974892433 cites W1999793372 @default.
- W1974892433 cites W2004703238 @default.
- W1974892433 cites W2013705864 @default.
- W1974892433 cites W2023542615 @default.
- W1974892433 cites W2026334721 @default.
- W1974892433 cites W2053875039 @default.
- W1974892433 cites W2059009119 @default.
- W1974892433 cites W2059617452 @default.
- W1974892433 cites W2083502135 @default.
- W1974892433 cites W2104048407 @default.
- W1974892433 cites W2104954806 @default.
- W1974892433 cites W2110345152 @default.
- W1974892433 cites W2115772647 @default.
- W1974892433 cites W2118453950 @default.
- W1974892433 cites W2124540225 @default.
- W1974892433 cites W2131822507 @default.
- W1974892433 cites W2139636031 @default.
- W1974892433 cites W2145294892 @default.
- W1974892433 cites W2147551208 @default.
- W1974892433 cites W2155643523 @default.
- W1974892433 cites W2161291398 @default.
- W1974892433 cites W2164174765 @default.
- W1974892433 cites W2082365856 @default.
- W1974892433 doi "https://doi.org/10.5483/bmbrep.2011.44.8.517" @default.
- W1974892433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21871175" @default.
- W1974892433 hasPublicationYear "2011" @default.
- W1974892433 type Work @default.
- W1974892433 sameAs 1974892433 @default.
- W1974892433 citedByCount "58" @default.
- W1974892433 countsByYear W19748924332012 @default.
- W1974892433 countsByYear W19748924332013 @default.
- W1974892433 countsByYear W19748924332014 @default.
- W1974892433 countsByYear W19748924332015 @default.
- W1974892433 countsByYear W19748924332016 @default.
- W1974892433 countsByYear W19748924332017 @default.
- W1974892433 countsByYear W19748924332018 @default.
- W1974892433 countsByYear W19748924332019 @default.
- W1974892433 countsByYear W19748924332020 @default.
- W1974892433 countsByYear W19748924332021 @default.
- W1974892433 countsByYear W19748924332022 @default.
- W1974892433 countsByYear W19748924332023 @default.
- W1974892433 crossrefType "journal-article" @default.
- W1974892433 hasAuthorship W1974892433A5038788451 @default.
- W1974892433 hasAuthorship W1974892433A5048952884 @default.
- W1974892433 hasAuthorship W1974892433A5057714274 @default.
- W1974892433 hasAuthorship W1974892433A5081859501 @default.
- W1974892433 hasAuthorship W1974892433A5082376747 @default.
- W1974892433 hasBestOaLocation W19748924331 @default.
- W1974892433 hasConcept C1491633281 @default.
- W1974892433 hasConcept C185592680 @default.
- W1974892433 hasConcept C18903297 @default.
- W1974892433 hasConcept C190283241 @default.
- W1974892433 hasConcept C191015642 @default.
- W1974892433 hasConcept C203522944 @default.
- W1974892433 hasConcept C2776306103 @default.
- W1974892433 hasConcept C2777229759 @default.
- W1974892433 hasConcept C28859421 @default.
- W1974892433 hasConcept C31573885 @default.
- W1974892433 hasConcept C55493867 @default.
- W1974892433 hasConcept C86803240 @default.
- W1974892433 hasConcept C95444343 @default.
- W1974892433 hasConceptScore W1974892433C1491633281 @default.
- W1974892433 hasConceptScore W1974892433C185592680 @default.
- W1974892433 hasConceptScore W1974892433C18903297 @default.
- W1974892433 hasConceptScore W1974892433C190283241 @default.
- W1974892433 hasConceptScore W1974892433C191015642 @default.
- W1974892433 hasConceptScore W1974892433C203522944 @default.
- W1974892433 hasConceptScore W1974892433C2776306103 @default.
- W1974892433 hasConceptScore W1974892433C2777229759 @default.
- W1974892433 hasConceptScore W1974892433C28859421 @default.
- W1974892433 hasConceptScore W1974892433C31573885 @default.
- W1974892433 hasConceptScore W1974892433C55493867 @default.
- W1974892433 hasConceptScore W1974892433C86803240 @default.
- W1974892433 hasConceptScore W1974892433C95444343 @default.
- W1974892433 hasIssue "8" @default.
- W1974892433 hasLocation W19748924331 @default.
- W1974892433 hasLocation W19748924332 @default.
- W1974892433 hasOpenAccess W1974892433 @default.
- W1974892433 hasPrimaryLocation W19748924331 @default.
- W1974892433 hasRelatedWork W1482038694 @default.
- W1974892433 hasRelatedWork W2010008722 @default.
- W1974892433 hasRelatedWork W2012224340 @default.
- W1974892433 hasRelatedWork W2055507365 @default.