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• W1974895114 startingPage "H480" @default.
• W1974895114 abstract "Tissue engineering may offer patients new options when replacement or repair of an organ is needed. However, most tissues will require a microvascular network to supply oxygen and nutrients. One strategy for creating a microvascular network would be promotion of vasculogenesis in situ by seeding vascular progenitor cells within the biopolymeric construct. To pursue this strategy, we isolated CD34+/CD133+ endothelial progenitor cells (EPC) from human umbilical cord blood and expanded the cells ex vivo as EPC-derived endothelial cells (EC). The EPC lost expression of the stem cell marker CD133 but continued to express the endothelial markers KDR/VEGF-R2, VE-cadherin, CD31, von Willebrand factor, and E-selectin. The cells were also shown to mediate calcium-dependent adhesion of HL-60 cells, a human promyelocytic leukemia cell line, providing evidence for a proinflammatory endothelial phenotype. The EPC-derived EC maintained this endothelial phenotype when expanded in roller bottles and subsequently seeded on polyglycolic acid-poly-l-lactic acid (PGA-PLLA) scaffolds, but microvessel formation was not observed. In contrast, EPC-derived EC seeded with human smooth muscle cells formed capillary-like structures throughout the scaffold (76.5 ± 35 microvessels/mm2). These results indicate that 1) EPC-derived EC can be expanded in vitro and seeded on biodegradable scaffolds with preservation of endothelial phenotype and 2) EPC-derived EC seeded with human smooth muscle cells form microvessels on porous PGA-PLLA scaffolds. These properties indicate that EPC may be well suited for creating microvascular networks within tissue-engineered constructs." @default.
• W1974895114 created "2016-06-24" @default.
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• W1974895114 date "2004-08-01" @default.
• W1974895114 modified "2023-09-30" @default.
• W1974895114 title "Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells" @default.
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• W1974895114 doi "https://doi.org/10.1152/ajpheart.01232.2003" @default.
• W1974895114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15277191" @default.
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