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- W1974895189 abstract "Increasing use of cannabis makes the search for medications to reduce cannabis abuse extremely important. Here, we show that homomeric α 7 nicotinic receptors are novel molecular entities that could be targeted in the development of new drugs for the treatment of cannabis dependence. In rats, systemic administration of the selective α 7 nicotinic acetylcholine receptor antagonist methyllycaconitine (MLA), but not the selective heteromeric non-α 7 nicotinic acetylcholine receptor antagonist dihydrobetaerythroidine, (1) antagonized the discriminative effects of δ-9-tetrahydrocannabinol (THC), the main active ingredient in cannabis, (2) reduced intravenous self-administration of the synthetic cannabinoid CB1 receptor agonist WIN55,212-2 [( R )-(+)-[2,3-dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone, mesylate salt], and (3) decreased THC-induced dopamine elevations in the shell of the nucleus accumbens. Altogether, our results indicate that blockade of α 7 nicotinic receptors reverses abuse-related behavioral and neurochemical effects of cannabinoids. Importantly, MLA reversed the effects of cannabinoids at doses that did not produce depressant or toxic effects, further pointing to α 7 nicotinic antagonists as potentially useful agents in the treatment of cannabis abuse in humans." @default.
- W1974895189 created "2016-06-24" @default.
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- W1974895189 date "2007-05-23" @default.
- W1974895189 modified "2023-10-10" @default.
- W1974895189 title "Nicotinic α<sub>7</sub>Receptors as a New Target for Treatment of Cannabis Abuse" @default.
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- W1974895189 doi "https://doi.org/10.1523/jneurosci.0027-07.2007" @default.
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