FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974897872> ?p ?o ?g. }

• W1974897872 endingPage "1002" @default.
• W1974897872 startingPage "998" @default.
• W1974897872 abstract "Cyclin-dependent kinase 5 (cdk5) is believed to be involved in the phosphorylation of tau protein. We studied the expression of the protein levels of cdk5 and the neuron-specific cdk5 activator p35 as well as cdk5 activity and tau phosphorylation during apoptosis in rat hippocampal neuronal cultures. We observed that in cells treated with etoposide, cyclosporin A, 4-hydroxynonenal (HNE), or okadaic acid, there was an early reduction in the protein levels of p35, and later also in cdk5 with all treatments except etoposide. The level of p25, a calpain cleavage product of p35 suggested to have increased ability to activate cdk5, was reduced paralleling the amount of p35. The changes in the p35 and p25 protein levels coincided with decreases in cdk5 activity and tau phosphorylation after treatment with HNE and etoposide. However, the relationship between the p35 and p25 levels and cdk5 activity was complex. We conclude that neuronal apoptosis is accompanied with a decrease in the levels of p35, p25, and cdk5, and tau phosphorylation. These changes may reinforce the neuronal damage." @default.
• W1974897872 created "2016-06-24" @default.
• W1974897872 creator A5010408163 @default.
• W1974897872 creator A5065493075 @default.
• W1974897872 creator A5076156274 @default.
• W1974897872 creator A5079862221 @default.
• W1974897872 creator A5080618425 @default.
• W1974897872 date "2001-02-01" @default.
• W1974897872 modified "2023-10-15" @default.
• W1974897872 title "The Levels of cdk5 and p35 Proteins and Tau Phosphorylation Are Reduced during Neuronal Apoptosis" @default.
• W1974897872 cites W1485329119 @default.
• W1974897872 cites W1563116834 @default.
• W1974897872 cites W1577397450 @default.
• W1974897872 cites W1836761553 @default.
• W1974897872 cites W1911014954 @default.
• W1974897872 cites W1963485518 @default.
• W1974897872 cites W1972273523 @default.
• W1974897872 cites W1979014608 @default.
• W1974897872 cites W1979268652 @default.
• W1974897872 cites W1982868475 @default.
• W1974897872 cites W1990922641 @default.
• W1974897872 cites W1993646884 @default.
• W1974897872 cites W2006526432 @default.
• W1974897872 cites W2009204794 @default.
• W1974897872 cites W2022782470 @default.
• W1974897872 cites W2028910078 @default.
• W1974897872 cites W2030269068 @default.
• W1974897872 cites W2031179697 @default.
• W1974897872 cites W2032095475 @default.
• W1974897872 cites W2047631658 @default.
• W1974897872 cites W2048560678 @default.
• W1974897872 cites W2053269070 @default.
• W1974897872 cites W2083451944 @default.
• W1974897872 cites W2088741011 @default.
• W1974897872 cites W2118159535 @default.
• W1974897872 cites W2122437043 @default.
• W1974897872 cites W2132503351 @default.
• W1974897872 cites W4237712827 @default.
• W1974897872 cites W4247406398 @default.
• W1974897872 doi "https://doi.org/10.1006/bbrc.2001.4240" @default.
• W1974897872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11162625" @default.
• W1974897872 hasPublicationYear "2001" @default.
• W1974897872 type Work @default.
• W1974897872 sameAs 1974897872 @default.
• W1974897872 citedByCount "34" @default.
• W1974897872 countsByYear W19748978722012 @default.
• W1974897872 countsByYear W19748978722013 @default.
• W1974897872 countsByYear W19748978722016 @default.
• W1974897872 countsByYear W19748978722017 @default.
• W1974897872 countsByYear W19748978722019 @default.
• W1974897872 crossrefType "journal-article" @default.
• W1974897872 hasAuthorship W1974897872A5010408163 @default.
• W1974897872 hasAuthorship W1974897872A5065493075 @default.
• W1974897872 hasAuthorship W1974897872A5076156274 @default.
• W1974897872 hasAuthorship W1974897872A5079862221 @default.
• W1974897872 hasAuthorship W1974897872A5080618425 @default.
• W1974897872 hasConcept C11960822 @default.
• W1974897872 hasConcept C121738310 @default.
• W1974897872 hasConcept C126322002 @default.
• W1974897872 hasConcept C170493617 @default.
• W1974897872 hasConcept C178666793 @default.
• W1974897872 hasConcept C181199279 @default.
• W1974897872 hasConcept C184235292 @default.
• W1974897872 hasConcept C185592680 @default.
• W1974897872 hasConcept C190283241 @default.
• W1974897872 hasConcept C2776953658 @default.
• W1974897872 hasConcept C2778670691 @default.
• W1974897872 hasConcept C2779134260 @default.
• W1974897872 hasConcept C502032728 @default.
• W1974897872 hasConcept C55493867 @default.
• W1974897872 hasConcept C56928146 @default.
• W1974897872 hasConcept C71924100 @default.
• W1974897872 hasConcept C82495950 @default.
• W1974897872 hasConcept C86803240 @default.
• W1974897872 hasConcept C88045685 @default.
• W1974897872 hasConcept C95444343 @default.
• W1974897872 hasConcept C97029542 @default.
• W1974897872 hasConceptScore W1974897872C11960822 @default.
• W1974897872 hasConceptScore W1974897872C121738310 @default.
• W1974897872 hasConceptScore W1974897872C126322002 @default.
• W1974897872 hasConceptScore W1974897872C170493617 @default.
• W1974897872 hasConceptScore W1974897872C178666793 @default.
• W1974897872 hasConceptScore W1974897872C181199279 @default.
• W1974897872 hasConceptScore W1974897872C184235292 @default.
• W1974897872 hasConceptScore W1974897872C185592680 @default.
• W1974897872 hasConceptScore W1974897872C190283241 @default.
• W1974897872 hasConceptScore W1974897872C2776953658 @default.
• W1974897872 hasConceptScore W1974897872C2778670691 @default.
• W1974897872 hasConceptScore W1974897872C2779134260 @default.
• W1974897872 hasConceptScore W1974897872C502032728 @default.
• W1974897872 hasConceptScore W1974897872C55493867 @default.
• W1974897872 hasConceptScore W1974897872C56928146 @default.
• W1974897872 hasConceptScore W1974897872C71924100 @default.
• W1974897872 hasConceptScore W1974897872C82495950 @default.
• W1974897872 hasConceptScore W1974897872C86803240 @default.
• W1974897872 hasConceptScore W1974897872C88045685 @default.
• W1974897872 hasConceptScore W1974897872C95444343 @default.
• W1974897872 hasConceptScore W1974897872C97029542 @default.

• next