FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974920489> ?p ?o ?g. }

• W1974920489 endingPage "499" @default.
• W1974920489 startingPage "492" @default.
• W1974920489 abstract "Salt-loading is an accelerator of hypertensive left ventricular (LV) remodeling. The relationship between salt-loading doses and the time window in which a transition from compensated to decompensated LV hypertrophy occurs in spontaneously hypertensive rats (SHR) is unclear. Eight-week-old male SHR and Wistar Kyoto rats (WKY) were randomized to receive normal (0.5% NaCl) and high salt diets (4% or 8% NaCl) for 12 weeks. Left ventricular remodeling was dynamically determined by echocardiography. LV invasive hemodynamics and morphologic staining [collagen deposition, cardiomyocte hypertrophy, DNA damage (8-hydroxy-2-deoxyguanosine, 8-OHdG) and apoptosis] were performed at time of sacrifice. Cardiac malonyldialdehyde (MDA) level was measured by ELISA. No differences between 4% and 8% salt diets, in terms of blood pressure (BP) levels, heart mass index, and myocardial fibrosis were observed either in SHR or in WKY. In high salt-loaded SHR, the LV ejection fraction and wall thickness peaked at 8 weeks after salt-loading, parallel with a progressive enlargement of the LV chamber size. Furthermore, when compared to 4% salt SHR, LV functions were significantly compromised in 8% salt SHR, accompanied by more prominent cardiomyoctye hypertrophy, oxidative stress (and related DNA damage), and apoptosis. Salt-loading for 12 weeks with 8% NaCl diet is more efficient to induce LV dysfunction than 4% NaCl diet does in SHR, possibly by initiating increased oxidative stress and resultant cardiac damage. Moreover, 8 to 12 weeks after 8% salt-loading is the key time window in which a transition from compensated to decompensated LV hypertrophy occurs." @default.
• W1974920489 created "2016-06-24" @default.
• W1974920489 creator A5002905137 @default.
• W1974920489 creator A5009337566 @default.
• W1974920489 creator A5063475696 @default.
• W1974920489 creator A5073192279 @default.
• W1974920489 creator A5078098268 @default.
• W1974920489 creator A5080862307 @default.
• W1974920489 creator A5088208044 @default.
• W1974920489 date "2011-05-02" @default.
• W1974920489 modified "2023-10-18" @default.
• W1974920489 title "High Salt Intake Accelerated Cardiac Remodeling in Spontaneously Hypertensive Rats: Time Window of Left Ventricular Functional Transition and Its Relation to Salt-Loading Doses" @default.
• W1974920489 cites W1542806971 @default.
• W1974920489 cites W1976183622 @default.
• W1974920489 cites W1976480176 @default.
• W1974920489 cites W1976538233 @default.
• W1974920489 cites W1976555160 @default.
• W1974920489 cites W1993177559 @default.
• W1974920489 cites W2002789236 @default.
• W1974920489 cites W2002868143 @default.
• W1974920489 cites W2002958873 @default.
• W1974920489 cites W2014145970 @default.
• W1974920489 cites W2014355830 @default.
• W1974920489 cites W2014542233 @default.
• W1974920489 cites W2016632251 @default.
• W1974920489 cites W2022544791 @default.
• W1974920489 cites W2026785826 @default.
• W1974920489 cites W2030662298 @default.
• W1974920489 cites W2052070549 @default.
• W1974920489 cites W2057150555 @default.
• W1974920489 cites W2058878434 @default.
• W1974920489 cites W2089273892 @default.
• W1974920489 cites W2089991723 @default.
• W1974920489 cites W2096073058 @default.
• W1974920489 cites W2107980062 @default.
• W1974920489 cites W2118260369 @default.
• W1974920489 cites W2120787301 @default.
• W1974920489 cites W2134819303 @default.
• W1974920489 cites W2147145830 @default.
• W1974920489 cites W2155732513 @default.
• W1974920489 cites W2166874140 @default.
• W1974920489 cites W2334229597 @default.
• W1974920489 cites W2336903283 @default.
• W1974920489 doi "https://doi.org/10.3109/10641963.2010.551795" @default.
• W1974920489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21529316" @default.
• W1974920489 hasPublicationYear "2011" @default.
• W1974920489 type Work @default.
• W1974920489 sameAs 1974920489 @default.
• W1974920489 citedByCount "17" @default.
• W1974920489 countsByYear W19749204892012 @default.
• W1974920489 countsByYear W19749204892013 @default.
• W1974920489 countsByYear W19749204892014 @default.
• W1974920489 countsByYear W19749204892015 @default.
• W1974920489 countsByYear W19749204892016 @default.
• W1974920489 countsByYear W19749204892017 @default.
• W1974920489 countsByYear W19749204892018 @default.
• W1974920489 countsByYear W19749204892019 @default.
• W1974920489 countsByYear W19749204892020 @default.
• W1974920489 countsByYear W19749204892021 @default.
• W1974920489 crossrefType "journal-article" @default.
• W1974920489 hasAuthorship W1974920489A5002905137 @default.
• W1974920489 hasAuthorship W1974920489A5009337566 @default.
• W1974920489 hasAuthorship W1974920489A5063475696 @default.
• W1974920489 hasAuthorship W1974920489A5073192279 @default.
• W1974920489 hasAuthorship W1974920489A5078098268 @default.
• W1974920489 hasAuthorship W1974920489A5080862307 @default.
• W1974920489 hasAuthorship W1974920489A5088208044 @default.
• W1974920489 hasConcept C126322002 @default.
• W1974920489 hasConcept C134018914 @default.
• W1974920489 hasConcept C164705383 @default.
• W1974920489 hasConcept C167414201 @default.
• W1974920489 hasConcept C178853913 @default.
• W1974920489 hasConcept C2776002628 @default.
• W1974920489 hasConcept C2776151105 @default.
• W1974920489 hasConcept C2778198053 @default.
• W1974920489 hasConcept C2779537366 @default.
• W1974920489 hasConcept C2780559512 @default.
• W1974920489 hasConcept C71924100 @default.
• W1974920489 hasConcept C78085059 @default.
• W1974920489 hasConcept C84393581 @default.
• W1974920489 hasConceptScore W1974920489C126322002 @default.
• W1974920489 hasConceptScore W1974920489C134018914 @default.
• W1974920489 hasConceptScore W1974920489C164705383 @default.
• W1974920489 hasConceptScore W1974920489C167414201 @default.
• W1974920489 hasConceptScore W1974920489C178853913 @default.
• W1974920489 hasConceptScore W1974920489C2776002628 @default.
• W1974920489 hasConceptScore W1974920489C2776151105 @default.
• W1974920489 hasConceptScore W1974920489C2778198053 @default.
• W1974920489 hasConceptScore W1974920489C2779537366 @default.
• W1974920489 hasConceptScore W1974920489C2780559512 @default.
• W1974920489 hasConceptScore W1974920489C71924100 @default.
• W1974920489 hasConceptScore W1974920489C78085059 @default.
• W1974920489 hasConceptScore W1974920489C84393581 @default.
• W1974920489 hasIssue "7" @default.
• W1974920489 hasLocation W19749204891 @default.
• W1974920489 hasLocation W19749204892 @default.
• W1974920489 hasOpenAccess W1974920489 @default.
• W1974920489 hasPrimaryLocation W19749204891 @default.

• next