Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974920590> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1974920590 endingPage "276" @default.
- W1974920590 startingPage "276" @default.
- W1974920590 abstract "Vascular endothelial growth factor (VEGF) up-regulates a number of cellular survival signals in endothelial cells. We hypothesize that VEGF will up-regulate survivin, a member of the IAP family of anti-apoptotic proteins, via the PI3K/Akt cell signaling pathway in human neuroblastoma cells.IMR-32 human neuroblastoma cells are cultured with VEGF at varying times and in escalating doses. A specific inhibitor of PI3-kinase, LY294002, is used to block Akt phosphorylation. Immunoblot is used to measure protein expression, and Hoechst staining is used to detect apoptosis.Stimulation of IMR-32 neuroblastoma cells with VEGF results in an increase in survivin protein expression in both a dose- and a time-dependent fashion. Akt phosphorylation is also increased after stimulation with exogenous VEGF. Blockade of Akt phosphorylation with LY294002 abrogates the effects of VEGF upon survivin and phosphorylated Akt protein expression.VEGF has been shown to up-regulate a number of survival signals in endothelial cells. We have found that exposure of human neuroblastoma cells to exogenous VEGF results in an increased expression of survivin protein and phosphorylated Akt, and inhibition of PI3-kinase abrogates those effects. It appears that VEGF is important for promotion of neuroblastoma cellular survival through the up-regulation of survival proteins, and not only through its angiogenic properties." @default.
- W1974920590 created "2016-06-24" @default.
- W1974920590 creator A5012334511 @default.
- W1974920590 creator A5022795218 @default.
- W1974920590 date "2008-09-01" @default.
- W1974920590 modified "2023-09-30" @default.
- W1974920590 title "PL-11 Diverse roles of STAT3 signaling in cancer" @default.
- W1974920590 doi "https://doi.org/10.1016/j.cyto.2008.07.217" @default.
- W1974920590 hasPublicationYear "2008" @default.
- W1974920590 type Work @default.
- W1974920590 sameAs 1974920590 @default.
- W1974920590 citedByCount "0" @default.
- W1974920590 crossrefType "journal-article" @default.
- W1974920590 hasAuthorship W1974920590A5012334511 @default.
- W1974920590 hasAuthorship W1974920590A5022795218 @default.
- W1974920590 hasConcept C11960822 @default.
- W1974920590 hasConcept C146285616 @default.
- W1974920590 hasConcept C167734588 @default.
- W1974920590 hasConcept C185592680 @default.
- W1974920590 hasConcept C190283241 @default.
- W1974920590 hasConcept C2775975398 @default.
- W1974920590 hasConcept C2776715637 @default.
- W1974920590 hasConcept C2776912716 @default.
- W1974920590 hasConcept C2777025900 @default.
- W1974920590 hasConcept C502942594 @default.
- W1974920590 hasConcept C54355233 @default.
- W1974920590 hasConcept C55493867 @default.
- W1974920590 hasConcept C62478195 @default.
- W1974920590 hasConcept C75217442 @default.
- W1974920590 hasConcept C81885089 @default.
- W1974920590 hasConcept C86554907 @default.
- W1974920590 hasConcept C86803240 @default.
- W1974920590 hasConcept C95444343 @default.
- W1974920590 hasConceptScore W1974920590C11960822 @default.
- W1974920590 hasConceptScore W1974920590C146285616 @default.
- W1974920590 hasConceptScore W1974920590C167734588 @default.
- W1974920590 hasConceptScore W1974920590C185592680 @default.
- W1974920590 hasConceptScore W1974920590C190283241 @default.
- W1974920590 hasConceptScore W1974920590C2775975398 @default.
- W1974920590 hasConceptScore W1974920590C2776715637 @default.
- W1974920590 hasConceptScore W1974920590C2776912716 @default.
- W1974920590 hasConceptScore W1974920590C2777025900 @default.
- W1974920590 hasConceptScore W1974920590C502942594 @default.
- W1974920590 hasConceptScore W1974920590C54355233 @default.
- W1974920590 hasConceptScore W1974920590C55493867 @default.
- W1974920590 hasConceptScore W1974920590C62478195 @default.
- W1974920590 hasConceptScore W1974920590C75217442 @default.
- W1974920590 hasConceptScore W1974920590C81885089 @default.
- W1974920590 hasConceptScore W1974920590C86554907 @default.
- W1974920590 hasConceptScore W1974920590C86803240 @default.
- W1974920590 hasConceptScore W1974920590C95444343 @default.
- W1974920590 hasIssue "3" @default.
- W1974920590 hasLocation W19749205901 @default.
- W1974920590 hasOpenAccess W1974920590 @default.
- W1974920590 hasPrimaryLocation W19749205901 @default.
- W1974920590 hasRelatedWork W2016686644 @default.
- W1974920590 hasRelatedWork W2022070430 @default.
- W1974920590 hasRelatedWork W2026216334 @default.
- W1974920590 hasRelatedWork W2051069156 @default.
- W1974920590 hasRelatedWork W2278983970 @default.
- W1974920590 hasRelatedWork W2394241628 @default.
- W1974920590 hasRelatedWork W2889491802 @default.
- W1974920590 hasRelatedWork W2890836849 @default.
- W1974920590 hasRelatedWork W2939547456 @default.
- W1974920590 hasRelatedWork W4255550893 @default.
- W1974920590 hasVolume "43" @default.
- W1974920590 isParatext "false" @default.
- W1974920590 isRetracted "false" @default.
- W1974920590 magId "1974920590" @default.
- W1974920590 workType "article" @default.