FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974934145> ?p ?o ?g. }

• W1974934145 endingPage "738" @default.
• W1974934145 startingPage "730" @default.
• W1974934145 abstract "Abstract Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD) pathophysiology and cognition in a nondemented elderly population. The biomarkers evaluated were brain Aβ load via Pittsburgh compound B (PiB)‐positron emission tomography (PET), neuronal dysfunction via 18 F‐fluorodeoxyglucose (FDG)‐PET, and neurodegeneration via structural magnetic resonance imaging (MRI). Methods: We studied 515 nondemented (428 cognitively normal and 87 mild cognitive impairment) participants in the population‐based Mayo Clinic Study of Aging who completed a 3T MRI, PET scans, and APOE genotype, and had lifestyle activity measures and cognition data available. The imaging measures computed were global PiB‐PET uptake, and global FDG‐PET and MRI based hippocampal volume. We consolidated activity variables into lifetime intellectual, current intellectual, and current physical activities. We used a global cognitive z score as a measure of cognition. We applied 2 independent methods—partial correlation analysis adjusted for age and gender and path analysis using structural equations—to evaluate the associations between lifestyle activities, imaging biomarkers, and global cognition. Results: None of the lifestyle variables were correlated with the biomarkers, and the path associations between lifestyle variables and biomarkers were not significant ( p > 0.05). Conversely, all the biomarkers were correlated with global cognitive z score ( p < 0.05), and the path associations between (lifetime and current) intellectual activities and global z score were significant ( p < 0.01). Interpretation: Intellectual and physical activity lifestyle factors were not associated with AD biomarkers, but intellectual lifestyle factors explained variability in the cognitive performance in this nondemented population. This study provides evidence that lifestyle activities may delay the onset of dementia but do not significantly influence the expression of AD pathophysiology. ANN NEUROL 2012;72:730–738" @default.
• W1974934145 created "2016-06-24" @default.
• W1974934145 creator A5001313680 @default.
• W1974934145 creator A5005099850 @default.
• W1974934145 creator A5013894575 @default.
• W1974934145 creator A5026250910 @default.
• W1974934145 creator A5030267127 @default.
• W1974934145 creator A5043583052 @default.
• W1974934145 creator A5043921358 @default.
• W1974934145 creator A5045246745 @default.
• W1974934145 creator A5057493616 @default.
• W1974934145 creator A5059027860 @default.
• W1974934145 creator A5066352714 @default.
• W1974934145 creator A5077933873 @default.
• W1974934145 date "2012-11-01" @default.
• W1974934145 modified "2023-10-18" @default.
• W1974934145 title "Effect of lifestyle activities on alzheimer disease biomarkers and cognition" @default.
• W1974934145 cites W1969787718 @default.
• W1974934145 cites W1984009511 @default.
• W1974934145 cites W1992841111 @default.
• W1974934145 cites W2003428745 @default.
• W1974934145 cites W2005355670 @default.
• W1974934145 cites W2007818439 @default.
• W1974934145 cites W2020780341 @default.
• W1974934145 cites W2028590992 @default.
• W1974934145 cites W2036234078 @default.
• W1974934145 cites W2044826080 @default.
• W1974934145 cites W2045794894 @default.
• W1974934145 cites W2052104903 @default.
• W1974934145 cites W2058046532 @default.
• W1974934145 cites W2059481988 @default.
• W1974934145 cites W2069016114 @default.
• W1974934145 cites W2078524519 @default.
• W1974934145 cites W2087651523 @default.
• W1974934145 cites W2092674727 @default.
• W1974934145 cites W2111399612 @default.
• W1974934145 cites W2129026667 @default.
• W1974934145 cites W2133719476 @default.
• W1974934145 cites W2134613265 @default.
• W1974934145 cites W2134717514 @default.
• W1974934145 cites W2141189151 @default.
• W1974934145 cites W2146310676 @default.
• W1974934145 cites W2146683638 @default.
• W1974934145 cites W2148079076 @default.
• W1974934145 cites W2151130155 @default.
• W1974934145 cites W2153859664 @default.
• W1974934145 cites W2157476687 @default.
• W1974934145 cites W2166207589 @default.
• W1974934145 cites W2167840686 @default.
• W1974934145 cites W2170891630 @default.
• W1974934145 cites W4238387639 @default.
• W1974934145 cites W4242276384 @default.
• W1974934145 cites W4252655171 @default.
• W1974934145 cites W51964316 @default.
• W1974934145 doi "https://doi.org/10.1002/ana.23665" @default.
• W1974934145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3539211" @default.
• W1974934145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23280791" @default.
• W1974934145 hasPublicationYear "2012" @default.
• W1974934145 type Work @default.
• W1974934145 sameAs 1974934145 @default.
• W1974934145 citedByCount "156" @default.
• W1974934145 countsByYear W19749341452013 @default.
• W1974934145 countsByYear W19749341452014 @default.
• W1974934145 countsByYear W19749341452015 @default.
• W1974934145 countsByYear W19749341452016 @default.
• W1974934145 countsByYear W19749341452017 @default.
• W1974934145 countsByYear W19749341452018 @default.
• W1974934145 countsByYear W19749341452019 @default.
• W1974934145 countsByYear W19749341452020 @default.
• W1974934145 countsByYear W19749341452021 @default.
• W1974934145 countsByYear W19749341452022 @default.
• W1974934145 countsByYear W19749341452023 @default.
• W1974934145 crossrefType "journal-article" @default.
• W1974934145 hasAuthorship W1974934145A5001313680 @default.
• W1974934145 hasAuthorship W1974934145A5005099850 @default.
• W1974934145 hasAuthorship W1974934145A5013894575 @default.
• W1974934145 hasAuthorship W1974934145A5026250910 @default.
• W1974934145 hasAuthorship W1974934145A5030267127 @default.
• W1974934145 hasAuthorship W1974934145A5043583052 @default.
• W1974934145 hasAuthorship W1974934145A5043921358 @default.
• W1974934145 hasAuthorship W1974934145A5045246745 @default.
• W1974934145 hasAuthorship W1974934145A5057493616 @default.
• W1974934145 hasAuthorship W1974934145A5059027860 @default.
• W1974934145 hasAuthorship W1974934145A5066352714 @default.
• W1974934145 hasAuthorship W1974934145A5077933873 @default.
• W1974934145 hasBestOaLocation W19749341452 @default.
• W1974934145 hasConcept C126322002 @default.
• W1974934145 hasConcept C126838900 @default.
• W1974934145 hasConcept C143409427 @default.
• W1974934145 hasConcept C15744967 @default.
• W1974934145 hasConcept C169760540 @default.
• W1974934145 hasConcept C169900460 @default.
• W1974934145 hasConcept C2775842073 @default.
• W1974934145 hasConcept C2779134260 @default.
• W1974934145 hasConcept C2779483572 @default.
• W1974934145 hasConcept C2781073650 @default.
• W1974934145 hasConcept C2908647359 @default.
• W1974934145 hasConcept C2984863031 @default.

• next