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• W1974941629 abstract "Studies suggest increased CT infection rates among women < 25 yrs, yet little is known about the developmental trajectory of infection in this population. We examined infection rates among adolescent women and association with age of sexual debut. Three hundred sixty women ages 14-19 were recruited from primary care clinics in Indianapolis, IN as part of a study involving quarterly screening for STIs. Subjects were grouped according to age of self reported sexual debut: ≤ 14 yrs, 15-16 yrs, and > 16 yrs. Comprehensive testing data from before, during, and after the study period was used to determine the number of distinct CT infections separated in time by documented treatment. Observation period was the time between the age at first sex and the age of last test. Rate was calculated using the total number of CT infections diagnosed over the observational period. Log-linear regression models (assuming a negative binomial distribution) were used to examine the effects of enrollment characteristics of subjects and STI history were used to model the rate of CT infections. A total of 984 CT infections were detected over 2,107 person-yrs for 360 women who reported age at first sex. Twenty-eight percent of subjects remained uninfected, 18.6% tested positive once, 17.2% tested positive twice, and 1% tested positive > 15 times for CT during observation. Sixty-five percent of participants reported age of sexual debut ≤ 14 years and 29% reported age of sexual debut between 15-16 yrs. Self reported mean age of first sex for all women was 13.93 yrs (± 1.68) and mean age of study enrollment was 15.38 yrs (± 1.06). There was no significant difference in rate of CT infection among subjects reporting first sex between 15-16 yrs (0.44) compared to those reporting first sex ≤ 14yrs (0.37) or those with first sex at age 17 or older (p = 0.64). Dropout rate did not differ by infection status at enrollment. There was no significant difference associated with the rate of infection and age at study enrollment. An increased rate of CT infections was associated with being positive for CT at enrollment; however, there was no association for those positive for GC or TV at enrollment. We found no evidence of increased rates CT infections based on age at first coitus. This result is inconsistent with prior suggestions of a biologic susceptibility of younger women. These data suggest that patterns of sexual activity, partner characteristics, specific sexual networks, and use of barrier protection are more important than age at first sex. These data suggest the need to reconsider assumptions about increased biological CT susceptibility among young adolescent women." @default.
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• W1974941629 date "2008-02-01" @default.
• W1974941629 modified "2023-09-25" @default.
• W1974941629 title "4: Chlamydia Trachomatis (CT) Infection Rate Is Not Associated with Age of Sexual Debut among Adolescent Women" @default.
• W1974941629 doi "https://doi.org/10.1016/j.jadohealth.2007.11.038" @default.
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