FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974948897> ?p ?o ?g. }

• W1974948897 endingPage "401" @default.
• W1974948897 startingPage "380" @default.
• W1974948897 abstract "Vascular aging, a determinant factor for cardiovascular disease and health status in the elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early hallmark of arterial aging that precedes the clinical manifestations of vascular dysfunction, the first step to cardiovascular disease and influencing vascular outcomes in the elderly. Accordingly, the preservation of endothelial function is thought to be an essential determinant of healthy aging. With special attention on the effects of aging on the endothelial function, this review is focused on the two main mechanisms of aging-related endothelial dysfunction: oxidative stress and inflammation. Aging vasculature generates an excess of the reactive oxygen species (ROS), superoxide and hydrogen peroxide, that compromise the vasodilatory activity of nitric oxide (NO) and facilitate the formation of the deleterious radical, peroxynitrite. Main sources of ROS are mitochondrial respiratory chain and NADPH oxidases, although NOS uncoupling could also account for ROS generation. In addition, reduced antioxidant response mediated by erythroid-2-related factor-2 (Nrf2) and downregulation of mitochondrial manganese superoxide dismutase (SOD2) contributes to the establishment of chronic oxidative stress in aged vessels. This is accompanied by a chronic low-grade inflammatory phenotype that participates in defective endothelial vasodilation. The redox-sensitive transcription factor, nuclear factor-κB (NF-κB), is upregulated in vascular cells from old subjects and drives a proinflammatory shift that feedbacks oxidative stress. This chronic NF-κB activation is contributed by increased angiotensin-II signaling and downregulated sirtuins and precludes adequate cellular response to acute ROS generation. Interventions targeted to recover endogenous antioxidant capacity and cellular stress response rather than exogenous antioxidants could reverse oxidative stress—inflammation vicious cycle in vascular aging. Lifestyle attitudes such as caloric restriction and exercise training appear as effective ways to overcome defective antioxidant response and inflammation, favoring successful vascular aging and decreasing the risk for cardiovascular disease." @default.
• W1974948897 created "2016-06-24" @default.
• W1974948897 creator A5004792362 @default.
• W1974948897 creator A5031618052 @default.
• W1974948897 creator A5058107727 @default.
• W1974948897 date "2013-12-01" @default.
• W1974948897 modified "2023-10-17" @default.
• W1974948897 title "Oxidative stress and vascular inflammation in aging" @default.
• W1974948897 cites W113297639 @default.
• W1974948897 cites W119636436 @default.
• W1974948897 cites W1490066329 @default.
• W1974948897 cites W1491181689 @default.
• W1974948897 cites W1495330546 @default.
• W1974948897 cites W1502614187 @default.
• W1974948897 cites W1522005099 @default.
• W1974948897 cites W1522271707 @default.
• W1974948897 cites W153305038 @default.
• W1974948897 cites W1538110087 @default.
• W1974948897 cites W1544929511 @default.
• W1974948897 cites W1550849850 @default.
• W1974948897 cites W1573222602 @default.
• W1974948897 cites W1578616085 @default.
• W1974948897 cites W1578883693 @default.
• W1974948897 cites W1581398548 @default.
• W1974948897 cites W1589837828 @default.
• W1974948897 cites W1590140680 @default.
• W1974948897 cites W1592269854 @default.
• W1974948897 cites W1599735426 @default.
• W1974948897 cites W1606828687 @default.
• W1974948897 cites W1608211496 @default.
• W1974948897 cites W1616268383 @default.
• W1974948897 cites W1658843865 @default.
• W1974948897 cites W1662930619 @default.
• W1974948897 cites W1693030104 @default.
• W1974948897 cites W1769035943 @default.
• W1974948897 cites W1775947750 @default.
• W1974948897 cites W1819259715 @default.
• W1974948897 cites W184020152 @default.
• W1974948897 cites W1946826431 @default.
• W1974948897 cites W1948805311 @default.
• W1974948897 cites W1963784744 @default.
• W1974948897 cites W1965117897 @default.
• W1974948897 cites W1965954516 @default.
• W1974948897 cites W1966780233 @default.
• W1974948897 cites W1968472971 @default.
• W1974948897 cites W1969995183 @default.
• W1974948897 cites W1970268166 @default.
• W1974948897 cites W1970459407 @default.
• W1974948897 cites W1970798352 @default.
• W1974948897 cites W1971448178 @default.
• W1974948897 cites W1972556189 @default.
• W1974948897 cites W1973103230 @default.
• W1974948897 cites W1974318726 @default.
• W1974948897 cites W1976770686 @default.
• W1974948897 cites W1978245407 @default.
• W1974948897 cites W1978655857 @default.
• W1974948897 cites W1978939238 @default.
• W1974948897 cites W1979171758 @default.
• W1974948897 cites W1979437866 @default.
• W1974948897 cites W1979705609 @default.
• W1974948897 cites W1981157440 @default.
• W1974948897 cites W1981477005 @default.
• W1974948897 cites W1981905227 @default.
• W1974948897 cites W1982512200 @default.
• W1974948897 cites W1983491805 @default.
• W1974948897 cites W1984662973 @default.
• W1974948897 cites W1984797661 @default.
• W1974948897 cites W1986064139 @default.
• W1974948897 cites W1987325894 @default.
• W1974948897 cites W1987652531 @default.
• W1974948897 cites W1988236300 @default.
• W1974948897 cites W1989025636 @default.
• W1974948897 cites W1989640659 @default.
• W1974948897 cites W1990787920 @default.
• W1974948897 cites W1991731804 @default.
• W1974948897 cites W1993498121 @default.
• W1974948897 cites W1995188356 @default.
• W1974948897 cites W1995219619 @default.
• W1974948897 cites W1997279646 @default.
• W1974948897 cites W1998288051 @default.
• W1974948897 cites W1998426553 @default.
• W1974948897 cites W1999718232 @default.
• W1974948897 cites W2001038193 @default.
• W1974948897 cites W2001252075 @default.
• W1974948897 cites W2001461795 @default.
• W1974948897 cites W2001752044 @default.
• W1974948897 cites W2001993791 @default.
• W1974948897 cites W2003614020 @default.
• W1974948897 cites W2004923406 @default.
• W1974948897 cites W2005024322 @default.
• W1974948897 cites W2005800951 @default.
• W1974948897 cites W2005822229 @default.
• W1974948897 cites W2007607879 @default.
• W1974948897 cites W2007643482 @default.
• W1974948897 cites W2007806456 @default.
• W1974948897 cites W2008542860 @default.
• W1974948897 cites W2009300287 @default.
• W1974948897 cites W2009931987 @default.

• next