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• W1974958384 endingPage "439" @default.
• W1974958384 startingPage "423" @default.
• W1974958384 abstract "Type I elements are multifunctional, cis-acting determinants that regulate the initiation of DNA replication, replication fork movement and transcription of the Tetrahymena thermophila rDNA minichromosome. Previous studies identified a protein, ssA-TIBF, that binds specifically to the A-rich strand of type I elements. Here, we examine interactions of ssA-TIBF with the wild-type C3 allele, and a natural variant, B rDNA, which manifests a defect in replication initiation and fork pausing. Purified ssA-TIBF is a homotetramer that binds one substrate molecule and contacts DNA via a single 24 kDa subunit. Both the A-rich and T-rich strands of type I elements are bound by ssA-TIBF, suggesting that this protein might stabilize replication origins in their unwound state. Nucleotides downstream of type I elements contribute to DNA binding, with the extent of DNA-protein contact being greater for wild-type C3 rDNA compared to B rDNA. Allele-specific protein-DNA contacts also occur within the conserved type I element itself. Despite these differences, the binding affinities of ssA-TIBF for C3 and B rDNA substrates are indistinguishable. Consequently, the mode of DNA binding must account for any role ssA-TIBF might play in the regulation of rDNA replication." @default.
• W1974958384 created "2016-06-24" @default.
• W1974958384 creator A5028315481 @default.
• W1974958384 creator A5037088287 @default.
• W1974958384 date "2000-01-01" @default.
• W1974958384 modified "2023-10-16" @default.
• W1974958384 title "Allele-specific protein-DNA interactions between the single-stranded DNA-binding protein, ssA-TIBF, and DNA replication determinants in Tetrahymena 1 1Edited by T. Richmond" @default.
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• W1974958384 doi "https://doi.org/10.1006/jmbi.1999.3365" @default.
• W1974958384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10623536" @default.
• W1974958384 hasPublicationYear "2000" @default.
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