FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974978275> ?p ?o ?g. }

• W1974978275 endingPage "29" @default.
• W1974978275 startingPage "22" @default.
• W1974978275 abstract "BackgroundNeonatal cardiac surgery evokes hyperglycemia and a systemic inflammatory response. Hyperglycemia is associated with intensified inflammation and adverse outcome in critically ill children and in pediatric cardiac surgery. Recently we demonstrated that tight glycemic control (TGC) reduced morbidity and mortality of critically ill children. Experimental data suggest that insulin protects the myocardium in the setting of ischemia-reperfusion injury, but this benefit could be blunted by coinciding hyperglycemia. We hypothesized that insulin-titrated TGC, initiated prior to myocardial ischemia and reperfusion, protects the myocardium and attenuates the inflammatory response after neonatal cardiac surgery.MethodsThis is a prospective randomized study at a university hospital. Fourteen neonates were randomized to intraoperative and postoperative conventional insulin therapy or TGC. Study endpoints were effects on myocardial damage and function; inflammation, endothelial activation, and clinical outcome parameters.ResultsTight glycemic control significantly reduced circulating levels of cardiac troponin-I (p = 0.009), heart fatty acid-binding protein (p = 0.01), B-type natriuretic peptide (p = 0.002), and the need for vasoactive support (p = 0.008). The TGC suppressed the rise of the proinflammatory cytokines interleukin-6 (p = 0.02) and interleukin-8 (p = 0.05), and reduced the postoperative increase in C-reactive protein (p = 0.04). Myocardial concentrations of Akt, endothelial nitric-oxide synthase, and their phosphorylated forms were not different between groups.ConclusionsIn neonates undergoing cardiac surgery, intraoperative and postoperative TGC protects the myocardium and reduces the inflammatory response. This appears not to be mediated by an early, direct insulin signaling effect, but may rather be due to independent effects of preventing hyperglycemia during reperfusion. Neonatal cardiac surgery evokes hyperglycemia and a systemic inflammatory response. Hyperglycemia is associated with intensified inflammation and adverse outcome in critically ill children and in pediatric cardiac surgery. Recently we demonstrated that tight glycemic control (TGC) reduced morbidity and mortality of critically ill children. Experimental data suggest that insulin protects the myocardium in the setting of ischemia-reperfusion injury, but this benefit could be blunted by coinciding hyperglycemia. We hypothesized that insulin-titrated TGC, initiated prior to myocardial ischemia and reperfusion, protects the myocardium and attenuates the inflammatory response after neonatal cardiac surgery. This is a prospective randomized study at a university hospital. Fourteen neonates were randomized to intraoperative and postoperative conventional insulin therapy or TGC. Study endpoints were effects on myocardial damage and function; inflammation, endothelial activation, and clinical outcome parameters. Tight glycemic control significantly reduced circulating levels of cardiac troponin-I (p = 0.009), heart fatty acid-binding protein (p = 0.01), B-type natriuretic peptide (p = 0.002), and the need for vasoactive support (p = 0.008). The TGC suppressed the rise of the proinflammatory cytokines interleukin-6 (p = 0.02) and interleukin-8 (p = 0.05), and reduced the postoperative increase in C-reactive protein (p = 0.04). Myocardial concentrations of Akt, endothelial nitric-oxide synthase, and their phosphorylated forms were not different between groups. In neonates undergoing cardiac surgery, intraoperative and postoperative TGC protects the myocardium and reduces the inflammatory response. This appears not to be mediated by an early, direct insulin signaling effect, but may rather be due to independent effects of preventing hyperglycemia during reperfusion." @default.
• W1974978275 created "2016-06-24" @default.
• W1974978275 creator A5008432179 @default.
• W1974978275 creator A5022809370 @default.
• W1974978275 creator A5023720567 @default.
• W1974978275 creator A5026600513 @default.
• W1974978275 creator A5035530316 @default.
• W1974978275 creator A5036267148 @default.
• W1974978275 creator A5042145557 @default.
• W1974978275 creator A5043406302 @default.
• W1974978275 creator A5053849098 @default.
• W1974978275 creator A5054077523 @default.
• W1974978275 creator A5063420890 @default.
• W1974978275 creator A5073823013 @default.
• W1974978275 date "2010-07-01" @default.
• W1974978275 modified "2023-09-27" @default.
• W1974978275 title "Tight Glycemic Control Protects the Myocardium and Reduces Inflammation in Neonatal Heart Surgery" @default.
• W1974978275 cites W1963984188 @default.
• W1974978275 cites W1969217210 @default.
• W1974978275 cites W1969441988 @default.
• W1974978275 cites W2008545806 @default.
• W1974978275 cites W2009832528 @default.
• W1974978275 cites W2022131685 @default.
• W1974978275 cites W2024020853 @default.
• W1974978275 cites W2026869194 @default.
• W1974978275 cites W2043723333 @default.
• W1974978275 cites W2051974518 @default.
• W1974978275 cites W2053609044 @default.
• W1974978275 cites W2054051454 @default.
• W1974978275 cites W2057914783 @default.
• W1974978275 cites W2069427959 @default.
• W1974978275 cites W2070901252 @default.
• W1974978275 cites W2082777570 @default.
• W1974978275 cites W2096409247 @default.
• W1974978275 cites W2098597607 @default.
• W1974978275 cites W2112980087 @default.
• W1974978275 cites W2117520303 @default.
• W1974978275 cites W2117980244 @default.
• W1974978275 cites W2119853884 @default.
• W1974978275 cites W2128166195 @default.
• W1974978275 cites W2129575932 @default.
• W1974978275 cites W2136494315 @default.
• W1974978275 cites W2136811318 @default.
• W1974978275 cites W2138373808 @default.
• W1974978275 cites W2141261411 @default.
• W1974978275 cites W2144358802 @default.
• W1974978275 cites W2150481072 @default.
• W1974978275 cites W2153316233 @default.
• W1974978275 cites W2157285381 @default.
• W1974978275 cites W2165972867 @default.
• W1974978275 cites W2168333632 @default.
• W1974978275 cites W2171176478 @default.
• W1974978275 cites W2322212663 @default.
• W1974978275 doi "https://doi.org/10.1016/j.athoracsur.2010.03.093" @default.
• W1974978275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20609741" @default.
• W1974978275 hasPublicationYear "2010" @default.
• W1974978275 type Work @default.
• W1974978275 sameAs 1974978275 @default.
• W1974978275 citedByCount "50" @default.
• W1974978275 countsByYear W19749782752012 @default.
• W1974978275 countsByYear W19749782752013 @default.
• W1974978275 countsByYear W19749782752014 @default.
• W1974978275 countsByYear W19749782752015 @default.
• W1974978275 countsByYear W19749782752016 @default.
• W1974978275 countsByYear W19749782752017 @default.
• W1974978275 countsByYear W19749782752018 @default.
• W1974978275 countsByYear W19749782752019 @default.
• W1974978275 countsByYear W19749782752020 @default.
• W1974978275 countsByYear W19749782752021 @default.
• W1974978275 countsByYear W19749782752022 @default.
• W1974978275 crossrefType "journal-article" @default.
• W1974978275 hasAuthorship W1974978275A5008432179 @default.
• W1974978275 hasAuthorship W1974978275A5022809370 @default.
• W1974978275 hasAuthorship W1974978275A5023720567 @default.
• W1974978275 hasAuthorship W1974978275A5026600513 @default.
• W1974978275 hasAuthorship W1974978275A5035530316 @default.
• W1974978275 hasAuthorship W1974978275A5036267148 @default.
• W1974978275 hasAuthorship W1974978275A5042145557 @default.
• W1974978275 hasAuthorship W1974978275A5043406302 @default.
• W1974978275 hasAuthorship W1974978275A5053849098 @default.
• W1974978275 hasAuthorship W1974978275A5054077523 @default.
• W1974978275 hasAuthorship W1974978275A5063420890 @default.
• W1974978275 hasAuthorship W1974978275A5073823013 @default.
• W1974978275 hasBestOaLocation W19749782751 @default.
• W1974978275 hasConcept C111566952 @default.
• W1974978275 hasConcept C115725540 @default.
• W1974978275 hasConcept C126322002 @default.
• W1974978275 hasConcept C134018914 @default.
• W1974978275 hasConcept C164027704 @default.
• W1974978275 hasConcept C164705383 @default.
• W1974978275 hasConcept C2776252253 @default.
• W1974978275 hasConcept C2776914184 @default.
• W1974978275 hasConcept C2778198053 @default.
• W1974978275 hasConcept C2778789114 @default.
• W1974978275 hasConcept C2778881276 @default.
• W1974978275 hasConcept C2779306644 @default.
• W1974978275 hasConcept C2780114680 @default.
• W1974978275 hasConcept C2780473172 @default.

• next