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- W1974991760 abstract "To the Editor.— Cocaine abuse is a major problem among methadonemaintained patients. 1 We recently tested the second generation antidepressant bupropion with six cocaine-dependent, methadone-maintained patients in an 8-week open pilot study. A test of the drug for the treatment of cocaine dependence was suggested by research showing that it directly influences dopaminergic transmission 2 and because it possesses few of the cardiovascular and anticholinergic side effects of first generation antidepressants. 3 Patients and Methods.— Six methadonemaintained patients participated in the study (two males and four females; mean [±SD] age, 35 ±11 years; daily mean [±SD] methadone dosage, 60 ±20 mg). All subjects were chronic intravenous cocaine users (mean [ ± SD] years of cocaine use, 12 ±8.2 years) who had used at least 0.5 g of cocaine per week for 3 months previous to entry into the study. All met DSM-III-R criteria for cocaine dependence. Subjects received 100 mg" @default.
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- W1974991760 date "1991-01-01" @default.
- W1974991760 modified "2023-10-18" @default.
- W1974991760 title "Bupropion Reduces Cocaine Abuse in Methadone-Maintained Patients" @default.
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- W1974991760 doi "https://doi.org/10.1001/archpsyc.1991.01810250089015" @default.
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