Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974996966> ?p ?o ?g. }
- W1974996966 endingPage "141" @default.
- W1974996966 startingPage "127" @default.
- W1974996966 abstract "8-Hydroxyguanine (8-OH-G) was discovered in 1983 in our laboratory at the National Cancer Center Research Institute, Tokyo. Since it could be formed in DNA not only in vitro but also in vivo by oxygen radical forming agents, we immediately hypothesized the importance of this discovery in connection with its biological consequence. Further intensive efforts by us from 1983 to 1990 confirmed that 8-OH-G is a highly significant oxidated DNA lesion involved in mutation and/or carcinogenesis in mammals, including humans. With the subsequent entry of many investigators to this research field the number of publications on 8-OH-G increased exponentially, reaching more than several thousands by the end of 2005. In this article, a summary is given of the important works carried out in the early days, and further notable contributions by many investigators are reviewed, focusing on 8-OH-G in the mammalian system. A special emphasis is given to research on knockout mice that are deficient in genes involved in the repair systems of the 8-OH-G lesion. Lastly, our own recent work is summarized involving a one-year carcinogenesis study of Ogg1 (the gene for 8-OH-G specific glycosylase/AP lyase) knockout mice that have been exposed to oxidative stress. (Communicated by Takao SEKIYA, M.J.A.)" @default.
- W1974996966 created "2016-06-24" @default.
- W1974996966 creator A5053311852 @default.
- W1974996966 date "2006-01-01" @default.
- W1974996966 modified "2023-09-28" @default.
- W1974996966 title "8-Hydroxyguanine: From its discovery in 1983 to the present status" @default.
- W1974996966 cites W1484882395 @default.
- W1974996966 cites W1518449135 @default.
- W1974996966 cites W1522788044 @default.
- W1974996966 cites W1558506222 @default.
- W1974996966 cites W1559534492 @default.
- W1974996966 cites W1594278418 @default.
- W1974996966 cites W1604322972 @default.
- W1974996966 cites W1850545464 @default.
- W1974996966 cites W1890612916 @default.
- W1974996966 cites W1919589075 @default.
- W1974996966 cites W1961851796 @default.
- W1974996966 cites W1964875336 @default.
- W1974996966 cites W1965121800 @default.
- W1974996966 cites W1967775878 @default.
- W1974996966 cites W1973059672 @default.
- W1974996966 cites W1973511453 @default.
- W1974996966 cites W1974410459 @default.
- W1974996966 cites W1976996879 @default.
- W1974996966 cites W1977060285 @default.
- W1974996966 cites W1980687864 @default.
- W1974996966 cites W1980742722 @default.
- W1974996966 cites W1982605253 @default.
- W1974996966 cites W1986647268 @default.
- W1974996966 cites W1986773920 @default.
- W1974996966 cites W1990751478 @default.
- W1974996966 cites W1997175051 @default.
- W1974996966 cites W1998426722 @default.
- W1974996966 cites W2003342971 @default.
- W1974996966 cites W2005338000 @default.
- W1974996966 cites W2007544926 @default.
- W1974996966 cites W2011076351 @default.
- W1974996966 cites W2011745892 @default.
- W1974996966 cites W2011803888 @default.
- W1974996966 cites W2011804819 @default.
- W1974996966 cites W2024755124 @default.
- W1974996966 cites W2026895762 @default.
- W1974996966 cites W2029243559 @default.
- W1974996966 cites W2030925250 @default.
- W1974996966 cites W2033136228 @default.
- W1974996966 cites W2033967426 @default.
- W1974996966 cites W2037211079 @default.
- W1974996966 cites W2041482709 @default.
- W1974996966 cites W2041683774 @default.
- W1974996966 cites W2043692125 @default.
- W1974996966 cites W2047001643 @default.
- W1974996966 cites W2052034749 @default.
- W1974996966 cites W2062646486 @default.
- W1974996966 cites W2064074750 @default.
- W1974996966 cites W2069477558 @default.
- W1974996966 cites W2071351849 @default.
- W1974996966 cites W2072013487 @default.
- W1974996966 cites W2074559096 @default.
- W1974996966 cites W2081145376 @default.
- W1974996966 cites W2084505555 @default.
- W1974996966 cites W2085855894 @default.
- W1974996966 cites W2085877659 @default.
- W1974996966 cites W2091403301 @default.
- W1974996966 cites W2093365277 @default.
- W1974996966 cites W2095301528 @default.
- W1974996966 cites W2095772473 @default.
- W1974996966 cites W2109870797 @default.
- W1974996966 cites W2110722235 @default.
- W1974996966 cites W2112773853 @default.
- W1974996966 cites W2113014296 @default.
- W1974996966 cites W2113320982 @default.
- W1974996966 cites W2120902002 @default.
- W1974996966 cites W2128953017 @default.
- W1974996966 cites W2132411923 @default.
- W1974996966 cites W2133487351 @default.
- W1974996966 cites W2137854060 @default.
- W1974996966 cites W2139137226 @default.
- W1974996966 cites W2139795906 @default.
- W1974996966 cites W2149179831 @default.
- W1974996966 cites W2151391072 @default.
- W1974996966 cites W2152096168 @default.
- W1974996966 cites W2152116092 @default.
- W1974996966 cites W2154828075 @default.
- W1974996966 cites W2163663923 @default.
- W1974996966 cites W2165966433 @default.
- W1974996966 cites W2169939490 @default.
- W1974996966 cites W2279579902 @default.
- W1974996966 cites W2289211117 @default.
- W1974996966 cites W2398650044 @default.
- W1974996966 cites W2400059493 @default.
- W1974996966 cites W2403306193 @default.
- W1974996966 cites W2404837748 @default.
- W1974996966 cites W69362276 @default.
- W1974996966 doi "https://doi.org/10.2183/pjab.82.127" @default.
- W1974996966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4323045" @default.
- W1974996966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25792776" @default.
- W1974996966 hasPublicationYear "2006" @default.
- W1974996966 type Work @default.