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• W1974998539 abstract "Abstract Background Mechanical stimulation of the mucosal epithelium results in increased serotonin (5‐ HT ) release from enterochromaffin ( EC ) cells. Little is known about how this process varies in different regions of the intestinal tract; however, purines are felt to play a role. We studied the relationship between mechanical stimulation, adenosine triphosphate ( ATP ), and 5‐ HT release from ileal and colonic mucosal tissue. Methods Amperometric recordings of ATP and 5‐ HT were carried out using an ATP biosensor and boron‐doped diamond microelectrode. Levels of extracellular ATP and 5‐ HT were monitored using high performance liquid chromatography. Key Results Under basal conditions, 5‐ HT levels were significantly decreased in the ileum ( p < 0.001) but not the colon in the presence of the P2 antagonist suramin (100 μ M). Ecto‐ ATP ase inhibitor ARL 67156 (10 μ M) elevated ATP levels in the ileum and colon (both p < 0.001), but only 5‐ HT levels in the ileum ( p < 0.001). Exogenous ATP increased 5‐ HT release in the presence of tetrodotoxin in the ileum ( p < 0.001), but had not effect in the colon. Mechanical stimulation increased levels of 5‐ HT in the ileum ( p < 0.001) and colon ( p < 0.01), but levels returned to baseline in the presence of suramin and MRS 2179 in the ileum. The onset of 5‐ HT release was delayed following mechanical stimulation. The rise time of the ATP response was quicker than that of 5‐ HT during mechanical stimulation. Conclusions & Inferences During mechanical stimulation of the mucosal epithelium, ATP mediates 5‐ HT release from EC cells in the ileum, but not the colon. Mucosal 5‐ HT signaling following mechanical stimulation is varied in different regions of the intestinal tract." @default.
• W1974998539 created "2016-06-24" @default.
• W1974998539 creator A5019425736 @default.
• W1974998539 date "2013-11-04" @default.
• W1974998539 modified "2023-10-03" @default.
• W1974998539 title "Mucosal adenosine triphosphate mediates serotonin release from ileal but not colonic guinea pig enterochromaffin cells" @default.
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• W1974998539 doi "https://doi.org/10.1111/nmo.12254" @default.
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