Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975000091> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1975000091 abstract "Nanopore-based sensing is an attractive candidate for developing single-molecule DNA sequencing technology. Recently, optical detection with a parallel nanopore array has been demonstrated. Although this method is a promising approach to develop high thorough-put measurement, the approach requires observation at low-background condition. In this paper, we propose a new optical method for nanopore DNA sequencing with high resolution and a high signal-tonoise ratio. We use ultraviolet light for the excitation of a fluorescent probe and a nanopore in a silicon membrane. Because silicon has a large refractive index and an extinction coefficient at ultraviolet wavelengths, light transmission thorough the membrane is negligible. This contributes to low background measurement of fluorescence from fluorophore-labeled DNA strands. In addition, the z-polarization component of the electric field is attributed to generating a large electric field gradient at the nanopore exit due to its boundary condition at the silicon surface. Our numerical electromagnetic simulation revealed that the z-component electric field was dominant compared to the xcomponent electric filed. The intensity of the electric field increased steeply in 2 nm, when ultraviolet light of 375nm wavelength was focused on a 10nm-thick silicon membrane with a 7 nm-diameter nanopore. This steeply increasing electric field can be sufficient resolution for the sequencing of designed DNA polymer. Finally, our experimental results demonstrated optical detection of single DNA translocation events with a high signal-to-noise ratio under applied voltage." @default.
- W1975000091 created "2016-06-24" @default.
- W1975000091 creator A5010121014 @default.
- W1975000091 creator A5041845498 @default.
- W1975000091 creator A5043306868 @default.
- W1975000091 creator A5045808953 @default.
- W1975000091 creator A5049819475 @default.
- W1975000091 creator A5088148995 @default.
- W1975000091 date "2014-02-20" @default.
- W1975000091 modified "2023-09-23" @default.
- W1975000091 title "Highly sensitive measurement of single DNA translocation through an ultraviolet light spot on silicon nanopore" @default.
- W1975000091 cites W1481296411 @default.
- W1975000091 cites W1964730348 @default.
- W1975000091 cites W1965002911 @default.
- W1975000091 cites W1972424189 @default.
- W1975000091 cites W1985601232 @default.
- W1975000091 cites W1991640081 @default.
- W1975000091 cites W1991674727 @default.
- W1975000091 cites W1993527536 @default.
- W1975000091 cites W2001947924 @default.
- W1975000091 cites W2009886994 @default.
- W1975000091 cites W2020646418 @default.
- W1975000091 cites W2029297547 @default.
- W1975000091 cites W2029758553 @default.
- W1975000091 cites W2030683115 @default.
- W1975000091 cites W2036105970 @default.
- W1975000091 cites W2059648430 @default.
- W1975000091 cites W2125021618 @default.
- W1975000091 cites W2129979528 @default.
- W1975000091 cites W2142962840 @default.
- W1975000091 cites W2146104357 @default.
- W1975000091 cites W2151207177 @default.
- W1975000091 cites W2165985585 @default.
- W1975000091 doi "https://doi.org/10.1117/12.2036648" @default.
- W1975000091 hasPublicationYear "2014" @default.
- W1975000091 type Work @default.
- W1975000091 sameAs 1975000091 @default.
- W1975000091 citedByCount "1" @default.
- W1975000091 countsByYear W19750000912021 @default.
- W1975000091 crossrefType "proceedings-article" @default.
- W1975000091 hasAuthorship W1975000091A5010121014 @default.
- W1975000091 hasAuthorship W1975000091A5041845498 @default.
- W1975000091 hasAuthorship W1975000091A5043306868 @default.
- W1975000091 hasAuthorship W1975000091A5045808953 @default.
- W1975000091 hasAuthorship W1975000091A5049819475 @default.
- W1975000091 hasAuthorship W1975000091A5088148995 @default.
- W1975000091 hasConcept C120665830 @default.
- W1975000091 hasConcept C121332964 @default.
- W1975000091 hasConcept C126513998 @default.
- W1975000091 hasConcept C141795571 @default.
- W1975000091 hasConcept C171250308 @default.
- W1975000091 hasConcept C185592680 @default.
- W1975000091 hasConcept C192562407 @default.
- W1975000091 hasConcept C2776798109 @default.
- W1975000091 hasConcept C2778617687 @default.
- W1975000091 hasConcept C2987116853 @default.
- W1975000091 hasConcept C49040817 @default.
- W1975000091 hasConcept C51679486 @default.
- W1975000091 hasConcept C544956773 @default.
- W1975000091 hasConcept C552990157 @default.
- W1975000091 hasConcept C55493867 @default.
- W1975000091 hasConcept C60799052 @default.
- W1975000091 hasConcept C62520636 @default.
- W1975000091 hasConcept C91881484 @default.
- W1975000091 hasConceptScore W1975000091C120665830 @default.
- W1975000091 hasConceptScore W1975000091C121332964 @default.
- W1975000091 hasConceptScore W1975000091C126513998 @default.
- W1975000091 hasConceptScore W1975000091C141795571 @default.
- W1975000091 hasConceptScore W1975000091C171250308 @default.
- W1975000091 hasConceptScore W1975000091C185592680 @default.
- W1975000091 hasConceptScore W1975000091C192562407 @default.
- W1975000091 hasConceptScore W1975000091C2776798109 @default.
- W1975000091 hasConceptScore W1975000091C2778617687 @default.
- W1975000091 hasConceptScore W1975000091C2987116853 @default.
- W1975000091 hasConceptScore W1975000091C49040817 @default.
- W1975000091 hasConceptScore W1975000091C51679486 @default.
- W1975000091 hasConceptScore W1975000091C544956773 @default.
- W1975000091 hasConceptScore W1975000091C552990157 @default.
- W1975000091 hasConceptScore W1975000091C55493867 @default.
- W1975000091 hasConceptScore W1975000091C60799052 @default.
- W1975000091 hasConceptScore W1975000091C62520636 @default.
- W1975000091 hasConceptScore W1975000091C91881484 @default.
- W1975000091 hasLocation W19750000911 @default.
- W1975000091 hasOpenAccess W1975000091 @default.
- W1975000091 hasPrimaryLocation W19750000911 @default.
- W1975000091 hasRelatedWork W1975000091 @default.
- W1975000091 hasRelatedWork W2319624216 @default.
- W1975000091 hasRelatedWork W2359271968 @default.
- W1975000091 hasRelatedWork W2365285091 @default.
- W1975000091 hasRelatedWork W263534722 @default.
- W1975000091 hasRelatedWork W3008479069 @default.
- W1975000091 hasRelatedWork W3017297538 @default.
- W1975000091 hasRelatedWork W3095933274 @default.
- W1975000091 hasRelatedWork W3160435484 @default.
- W1975000091 hasRelatedWork W4327518374 @default.
- W1975000091 isParatext "false" @default.
- W1975000091 isRetracted "false" @default.
- W1975000091 magId "1975000091" @default.
- W1975000091 workType "article" @default.