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• W1975008431 abstract "The effects of YM‐60828, a newly synthesized factor Xa inhibitor, were investigated to analyse the relationship between its antithrombotic effects and its prolongation of template bleeding time in rats. YM‐60828 was compared with argatroban, heparin and dalteparin. All agents were intravenously administered as a bolus. In ex vivo studies, YM‐60828 and argatroban prolonged both prothrombin time and activated partial thromboplastin time in a dose‐dependent manner, while heparin and dalteparin prolonged only activated partial thromboplastin time. In a venous thrombosis model, all agents exerted antithrombotic effects in a dose‐dependent manner. The ID 50 values of YM‐60828, argatroban, heparin and dalteparin were 0.0081 mg kg −1 , 0.011 mg kg −1 , 6.3 iu kg −1 and 4.7 iu kg −1 , respectively. In an arterio‐venous shunt model, all agents exerted antithrombotic effects in a dose‐dependent manner. The ID 50 values of YM‐60828, argatroban, heparin and dalteparin were 0.010 mg kg −1 , 0.011 mg kg −1 , 10 iu kg −1 and 4.2 iu kg −1 , respectively. In bleeding time studies, all agents prolonged template bleeding time in a dose‐dependent manner. ED 2 values, the doses causing a 2 fold prolongation of bleeding time in the saline group, of YM‐60828, argatroban, heparin and dalteparin were 0.76 mg kg −1 , 0.081 mg kg −1 , 18 iu kg −1 and 25 iu kg −1 , respectively. The ratio (ED 2 /ID 50 ) of YM‐60828 was more than 30 fold greater than that of heparin and more than 10 fold greater than those of argatroban and dalteparin. These data show that YM‐60828 can exert its antithrombotic effects with little prolongation of bleeding time compared with the other currently used anticoagulant agents. British Journal of Pharmacology (1998) 123 , 92–96; doi: 10.1038/sj.bjp.0701566" @default.
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• W1975008431 date "1998-01-01" @default.
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• W1975008431 title "Antithrombotic effects of YM‐60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time" @default.
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• W1975008431 doi "https://doi.org/10.1038/sj.bjp.0701566" @default.
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