Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975008955> ?p ?o ?g. }
- W1975008955 endingPage "17" @default.
- W1975008955 startingPage "1" @default.
- W1975008955 abstract "To investigate the effect of fluoxetine on serotonergic sensitivity in obsessive-compulsive disorder (OCD), the partial serotonin agonist metachlorophenylpiperazine (mCPP) was compared to placebo under double-blind conditions in six patients with OCD before and during treatment with fluoxetine. Readministration of oral mCPP (0.5 mg/kg) after at least 12 weeks of fluoxetine treatment did not increase obsessive-compulsive (OC) symptoms, in contrast to exacerbation of OC symptoms produced by mCPP before treatment. Chronic fluoxetine treatment resulted in a significant increase in prolactin and cortisol response to mCPP. This may be accounted for, however, by substantially increased plasma mCPP levels during fluoxetine treatment. Chronic fluoxetine treatment diminished the behavioral sensitivity to mCPP and did not diminish, but may have partially normalized, the neuroendocrine response to mCPP in patients with OCD. These adaptive homeostatic effects may reflect fluoxetine's antiobsessional mechanism." @default.
- W1975008955 created "2016-06-24" @default.
- W1975008955 creator A5004990608 @default.
- W1975008955 creator A5025902845 @default.
- W1975008955 creator A5025914671 @default.
- W1975008955 creator A5032136657 @default.
- W1975008955 creator A5041287581 @default.
- W1975008955 creator A5054302618 @default.
- W1975008955 creator A5060032203 @default.
- W1975008955 creator A5064462389 @default.
- W1975008955 date "1991-01-01" @default.
- W1975008955 modified "2023-10-01" @default.
- W1975008955 title "Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to meta-chloro-phenylpiperazine in obsessive-compulsive disorder" @default.
- W1975008955 cites W1864568504 @default.
- W1975008955 cites W1970495368 @default.
- W1975008955 cites W1978112735 @default.
- W1975008955 cites W1980290422 @default.
- W1975008955 cites W1981443436 @default.
- W1975008955 cites W1987190103 @default.
- W1975008955 cites W1987190509 @default.
- W1975008955 cites W1991656260 @default.
- W1975008955 cites W2002780074 @default.
- W1975008955 cites W2007725150 @default.
- W1975008955 cites W2010335416 @default.
- W1975008955 cites W2013997031 @default.
- W1975008955 cites W2014089412 @default.
- W1975008955 cites W2029338703 @default.
- W1975008955 cites W2030642857 @default.
- W1975008955 cites W2031769899 @default.
- W1975008955 cites W2033472966 @default.
- W1975008955 cites W2038361574 @default.
- W1975008955 cites W2044069518 @default.
- W1975008955 cites W2052474780 @default.
- W1975008955 cites W2065190583 @default.
- W1975008955 cites W2065955580 @default.
- W1975008955 cites W2067160581 @default.
- W1975008955 cites W2072246350 @default.
- W1975008955 cites W2075144107 @default.
- W1975008955 cites W2075570771 @default.
- W1975008955 cites W2077466070 @default.
- W1975008955 cites W2082593045 @default.
- W1975008955 cites W2092326568 @default.
- W1975008955 cites W2092356890 @default.
- W1975008955 cites W2097231409 @default.
- W1975008955 cites W2109489224 @default.
- W1975008955 cites W2155624304 @default.
- W1975008955 cites W23153590 @default.
- W1975008955 cites W2341195774 @default.
- W1975008955 cites W2345998241 @default.
- W1975008955 cites W2467561602 @default.
- W1975008955 cites W2086894297 @default.
- W1975008955 doi "https://doi.org/10.1016/0165-1781(91)90113-4" @default.
- W1975008955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2017519" @default.
- W1975008955 hasPublicationYear "1991" @default.
- W1975008955 type Work @default.
- W1975008955 sameAs 1975008955 @default.
- W1975008955 citedByCount "116" @default.
- W1975008955 countsByYear W19750089552012 @default.
- W1975008955 countsByYear W19750089552013 @default.
- W1975008955 countsByYear W19750089552014 @default.
- W1975008955 countsByYear W19750089552015 @default.
- W1975008955 countsByYear W19750089552017 @default.
- W1975008955 countsByYear W19750089552020 @default.
- W1975008955 countsByYear W19750089552022 @default.
- W1975008955 crossrefType "journal-article" @default.
- W1975008955 hasAuthorship W1975008955A5004990608 @default.
- W1975008955 hasAuthorship W1975008955A5025902845 @default.
- W1975008955 hasAuthorship W1975008955A5025914671 @default.
- W1975008955 hasAuthorship W1975008955A5032136657 @default.
- W1975008955 hasAuthorship W1975008955A5041287581 @default.
- W1975008955 hasAuthorship W1975008955A5054302618 @default.
- W1975008955 hasAuthorship W1975008955A5060032203 @default.
- W1975008955 hasAuthorship W1975008955A5064462389 @default.
- W1975008955 hasConcept C126322002 @default.
- W1975008955 hasConcept C134018914 @default.
- W1975008955 hasConcept C142724271 @default.
- W1975008955 hasConcept C15744967 @default.
- W1975008955 hasConcept C170493617 @default.
- W1975008955 hasConcept C204787440 @default.
- W1975008955 hasConcept C27081682 @default.
- W1975008955 hasConcept C2775864247 @default.
- W1975008955 hasConcept C2776134451 @default.
- W1975008955 hasConcept C2777014857 @default.
- W1975008955 hasConcept C2777669559 @default.
- W1975008955 hasConcept C2779064019 @default.
- W1975008955 hasConcept C2779177272 @default.
- W1975008955 hasConcept C2781161787 @default.
- W1975008955 hasConcept C2909992730 @default.
- W1975008955 hasConcept C31487548 @default.
- W1975008955 hasConcept C37000724 @default.
- W1975008955 hasConcept C71315377 @default.
- W1975008955 hasConcept C71924100 @default.
- W1975008955 hasConceptScore W1975008955C126322002 @default.
- W1975008955 hasConceptScore W1975008955C134018914 @default.
- W1975008955 hasConceptScore W1975008955C142724271 @default.
- W1975008955 hasConceptScore W1975008955C15744967 @default.
- W1975008955 hasConceptScore W1975008955C170493617 @default.
- W1975008955 hasConceptScore W1975008955C204787440 @default.