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- W1975010709 abstract "Chemotherapy-associated liver injury is a major cause for concern when treating patients with colorectal liver metastases. The aim of this review was to determine the pathological effect of specific chemotherapy regimens on the hepatic parenchyma as well as on surgical morbidity, mortality and overall survival. A systematic review of the published literature and a meta-analysis were performed. For each of the variables under consideration, the effects of different chemotherapy regimens were determined by calculation of relative risks by a random-effects model. Hepatic parenchymal injury is regimen specific, with oxaliplatin-based regimens being associated with grade 2 or greater sinusoidal injury (number needed to harm 8; 95 % confidence interval [CI] 6.4–13.6), whereas irinotecan-based regimens associated with steatohepatitis (number needed to harm 12; 95 % CI 7.8–26). The use of bevacizumab alongside FOLFOX reduces the risk of grade 2 or greater sinusoidal injury (relative risk 0.34; 95 % CI 0.15–0.75). Chemotherapy before resection of colorectal liver metastases is associated with an increased risk of regimen-specific liver injury. This liver injury may have implications for the functional reserve of the liver for patients undergoing major hepatectomy for colorectal liver metastases." @default.
- W1975010709 created "2016-06-24" @default.
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- W1975010709 date "2012-07-06" @default.
- W1975010709 modified "2023-10-11" @default.
- W1975010709 title "Chemotherapy-Associated Liver Injury in Patients with Colorectal Liver Metastases: A Systematic Review and Meta-analysis" @default.
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- W1975010709 doi "https://doi.org/10.1245/s10434-012-2438-8" @default.
- W1975010709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3505531" @default.
- W1975010709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22766981" @default.
- W1975010709 hasPublicationYear "2012" @default.
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