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- W1975013245 abstract "Ethanol stimulates the Na+-dependent Ca2+ efflux in brain mitochondria and inhibits the Na+-independent Ca2+-efflux [12]. Here, we studied the effects of n-alkanols on the various Ca2+ transport processes in brain mitochondria. Only short-chain alcohols (i.e. methanol, ethanol and propanol) stimulated Na+Ca2+ exchange. The inhibition of H+Ca2+ exchange was significant only with ethanol. Short-chain alcohols inhibit while long-chain alcohols activate the cyclosporin-sensitive Ca2+-efflux. These data suggest that the mechanism of the alkanols' effects on Na+Ca2+ exchange, H+Ca2+ exchange and the cyclosporin sensitive pore are entirely different. Alkanols have no effect on the electrogenic Ca2+ uniporter. Ethanol did not affect the apparent K0.5 for Na+ (7.5 mM) of the Na+Ca2+ exchange. Similarly, the magnitude of the effect of ethanol did not depend on matrix Ca2+ concentration, suggesting that short-chain alkanols do not stimulate the rate of Na+Ca2+ exchange by increasing the affinity of the carrier to Ca2+in or Na+out. High concentrations of K+, Mg2+ and Ca2+ enhanced the ethanol effect. It is possible that high surface potential attenuates the effect of ethanol. It is suggested that ethanol stimulation of Na+Ca2+ exchange depends on the modulation of the surface dielectric constant." @default.
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- W1975013245 date "1992-01-01" @default.
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- W1975013245 title "The effect of alkanols on Ca2+ transport in brain mitochondria" @default.
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- W1975013245 doi "https://doi.org/10.1016/0143-4160(92)90028-q" @default.
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