FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975041628> ?p ?o ?g. }

• W1975041628 endingPage "33" @default.
• W1975041628 startingPage "23" @default.
• W1975041628 abstract "Store-operated Ca(2+) entry channels (SOCs) play an important role in the regulation of diverse non-excitable cell functions. However, the precise mechanism of SOCs activation is still controversial. Uridine 5'-triphosphate (UTP) was shown to induce Ca(2+) entry in a dihydropyridines-insensitive manner and accelerated steroidogenesis in bovine adrenocortical fasciculata cells (BAFCs) via the Gq/11 protein-coupled P2Y(2) receptor. Therefore we investigated whether UTP is involved in SOCs activation and the mechanism of UTP-induced SOCs activation. Fura 2-loaded BAFCs were used for the measurement of intracellular concentration of Ca(2+) ([Ca(2+)](i)) mobilization. Extracellular UTP evoked Ca(2+) release from intracellular stores followed by an increase in Ca(2+) entry. The Ca(2+) influx elicited by UTP was inhibited not by nifedipine, but by Zn(2+), Cd(2+), and Ni(2+) (potency order: Zn(2+) > Cd(2+) >> Ni(2+)), and the effect of UTP was also attenuated by a phospholipase C inhibitor (U73122). These results indicate that UTP activates SOCs in BAFCs. The increase in [Ca(2+)](i) by UTP was attenuated by ML-9, a myosin-light chain kinase inhibitor, and calmodulin inhibitors, W-7 and E6 berbamine, in a concentration-dependent manner. These reagents depolymerized actin filaments with rhodamine staining in BAFCs. Cytochalasin D also inhibited UTP-activated SOCs and depolymerized actin filaments. From these results, we proposed that calcium/calmodulin dependent myosin-light chain kinase is involved in the mobilization of actin filaments and the integrity of actin-network plays an important role in UTP-induced SOCs activation in BAFCs." @default.
• W1975041628 created "2016-06-24" @default.
• W1975041628 creator A5011900166 @default.
• W1975041628 creator A5016293152 @default.
• W1975041628 creator A5024237397 @default.
• W1975041628 creator A5027360980 @default.
• W1975041628 creator A5054418003 @default.
• W1975041628 creator A5058149642 @default.
• W1975041628 creator A5068749796 @default.
• W1975041628 date "2003-01-01" @default.
• W1975041628 modified "2023-09-24" @default.
• W1975041628 title "Integrity of Actin-Network Is Involved in Uridine 5'-Triphosphate Evoked Store-Operated Ca2+ Entry in Bovine Adrenocortical Fasciculata Cells" @default.
• W1975041628 cites W1498131948 @default.
• W1975041628 cites W1498427480 @default.
• W1975041628 cites W1560179018 @default.
• W1975041628 cites W1571332834 @default.
• W1975041628 cites W1599213556 @default.
• W1975041628 cites W1874327812 @default.
• W1975041628 cites W1934331785 @default.
• W1975041628 cites W1958244357 @default.
• W1975041628 cites W1964123069 @default.
• W1975041628 cites W1965920570 @default.
• W1975041628 cites W1978227610 @default.
• W1975041628 cites W1984888793 @default.
• W1975041628 cites W1985086376 @default.
• W1975041628 cites W1991602526 @default.
• W1975041628 cites W1992471713 @default.
• W1975041628 cites W1993904794 @default.
• W1975041628 cites W1994003713 @default.
• W1975041628 cites W1995786530 @default.
• W1975041628 cites W1998606603 @default.
• W1975041628 cites W1999952388 @default.
• W1975041628 cites W2002441736 @default.
• W1975041628 cites W2005584034 @default.
• W1975041628 cites W2008714195 @default.
• W1975041628 cites W2023022110 @default.
• W1975041628 cites W2028684902 @default.
• W1975041628 cites W2030292005 @default.
• W1975041628 cites W2036436959 @default.
• W1975041628 cites W2041690080 @default.
• W1975041628 cites W2044767937 @default.
• W1975041628 cites W2051824182 @default.
• W1975041628 cites W2053086647 @default.
• W1975041628 cites W2054675070 @default.
• W1975041628 cites W2058180049 @default.
• W1975041628 cites W2065256692 @default.
• W1975041628 cites W2068162116 @default.
• W1975041628 cites W2069364360 @default.
• W1975041628 cites W2070832223 @default.
• W1975041628 cites W2072933582 @default.
• W1975041628 cites W2077835292 @default.
• W1975041628 cites W2078663076 @default.
• W1975041628 cites W2082127635 @default.
• W1975041628 cites W2083073734 @default.
• W1975041628 cites W2083445763 @default.
• W1975041628 cites W2096437759 @default.
• W1975041628 cites W2099757747 @default.
• W1975041628 cites W2130851152 @default.
• W1975041628 cites W2151271805 @default.
• W1975041628 cites W2261451688 @default.
• W1975041628 cites W2266038146 @default.
• W1975041628 cites W2345003741 @default.
• W1975041628 cites W2440701475 @default.
• W1975041628 doi "https://doi.org/10.1254/jphs.91.23" @default.
• W1975041628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12686727" @default.
• W1975041628 hasPublicationYear "2003" @default.
• W1975041628 type Work @default.
• W1975041628 sameAs 1975041628 @default.
• W1975041628 citedByCount "13" @default.
• W1975041628 countsByYear W19750416282013 @default.
• W1975041628 countsByYear W19750416282020 @default.
• W1975041628 crossrefType "journal-article" @default.
• W1975041628 hasAuthorship W1975041628A5011900166 @default.
• W1975041628 hasAuthorship W1975041628A5016293152 @default.
• W1975041628 hasAuthorship W1975041628A5024237397 @default.
• W1975041628 hasAuthorship W1975041628A5027360980 @default.
• W1975041628 hasAuthorship W1975041628A5054418003 @default.
• W1975041628 hasAuthorship W1975041628A5058149642 @default.
• W1975041628 hasAuthorship W1975041628A5068749796 @default.
• W1975041628 hasBestOaLocation W19750416281 @default.
• W1975041628 hasConcept C104317684 @default.
• W1975041628 hasConcept C125705527 @default.
• W1975041628 hasConcept C142669718 @default.
• W1975041628 hasConcept C1491633281 @default.
• W1975041628 hasConcept C160225129 @default.
• W1975041628 hasConcept C181199279 @default.
• W1975041628 hasConcept C184235292 @default.
• W1975041628 hasConcept C185592680 @default.
• W1975041628 hasConcept C201800478 @default.
• W1975041628 hasConcept C2775995422 @default.
• W1975041628 hasConcept C2776041460 @default.
• W1975041628 hasConcept C2778564976 @default.
• W1975041628 hasConcept C2778597717 @default.
• W1975041628 hasConcept C28406088 @default.
• W1975041628 hasConcept C29688787 @default.
• W1975041628 hasConcept C512185932 @default.
• W1975041628 hasConcept C55493867 @default.
• W1975041628 hasConcept C57306754 @default.

• next