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- W197505909 abstract "To assess the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotypes to unexplained recurrent spontaneous abortion (URSA).This study included two groups:57 currently non-pregnant women with a history of URSA (URSA group), and 50 currently non-pregnant women with a history of having given birth to at least one live baby and without any history of spontaneous abortion, still-born fetus, placental thrombosis and intrauterine growth retardation(IUGR)(control group). The fasting serum-Hcy was measured with high pressure liquid chromatography. Folic acid and vitamin B(12) were detected by radioimmune assay; antiphospholipid antibody (ACA) was detected by ELISA. MTHFR C677T gene polymorphisms were detected by the technique of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).C/C genotype in URSA group was significantly lower than that in control group, the total mutant T allele frequency was significantly higher than that in control group. There was no significant difference in respect of age, rural area/city, period, primary/secondary abortion between the genotype distributions of MTHFR C677T. The T/T genotype and C/T+T/T genotypes frequencies for abortion times>or=3 were higher than those for abortion time <3.MTHFR C677T gene polymorphism is a genetic risk factor for URSA." @default.
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- W197505909 date "2004-02-01" @default.
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- W197505909 title "[Study on the relationship of MTHFR polymorphisms with unexplained recurrent spontaneous abortion]." @default.
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