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• W1975060133 abstract "No AccessJournal of UrologyClinical Urology: Original Articles1 May 1998A POSSIBLE MECHANISM FOR ALTERATION OF HUMAN ERECTILE FUNCTION BY DIGOXIN: INHIBITION OF CORPUS CAVERNOSUM SODIUM/POTASSIUM ADENOSINE TRIPHOSPHATASE ACTIVITY SANDEEP GUPTA, PEDRAM SALIMPOUR, INIGO SAENZ DE TEJADA, JENNIFER DALEY, SHAHRAM GHOLAMI, MEIR DALLER, ROBERT J. KRANE, ABDUL M. TRAISH, and IRWIN GOLDSTEIN SANDEEP GUPTASANDEEP GUPTA (GUPTA) Recipient of the NIH Basic Science Cardiovascular Training Grant T 32 HL07224-19. Current address: Division of Urology, University of Pennsylvania School of Medicine, 3400 Spruce St., Philadelphia, Pennsylvania 19104-4283. More articles by this author , PEDRAM SALIMPOURPEDRAM SALIMPOUR More articles by this author , INIGO SAENZ DE TEJADAINIGO SAENZ DE TEJADA More articles by this author , JENNIFER DALEYJENNIFER DALEY More articles by this author , SHAHRAM GHOLAMISHAHRAM GHOLAMI More articles by this author , MEIR DALLERMEIR DALLER More articles by this author , ROBERT J. KRANEROBERT J. KRANE More articles by this author , ABDUL M. TRAISHABDUL M. TRAISH More articles by this author , and IRWIN GOLDSTEINIRWIN GOLDSTEIN More articles by this author View All Author Informationhttps://doi.org/10.1097/00005392-199805000-00033AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Digoxin use has long been recognized to affect adversely male sexual function but the underlying mechanism is poorly understood. Digoxin is a known inhibitor of sodium/potassium adenosine triphosphatase (sodium pump), a plasma membrane enzyme that has a role in the regulation of smooth muscle tone. We investigated the effects of digoxin on human corpus cavernosum smooth muscle contractility and overall erectile function. Materials and Methods: In human corporeal smooth muscle strips the in vitro effects of digoxin were assessed on sodium pump activity as measured by digoxin inhibitable uptake of86 rubidium, basal tone and endothelium dependent, neurogenic and nitric oxide donor induced relaxation. An in vivo prospective double-blind, placebo controlled, crossover, 4-period investigation was performed in 6 healthy male volunteers. The effects of digoxin on serum hormones, erectile function questionnaire, visual sexual stimulation and nocturnal penile tumescence were recorded. Results: In vitro digoxin caused concentration dependent inhibition of (86) rubidium uptake (half maximum effect at 0.01 micro M.) and contraction of corporeal smooth muscle (half maximum effect at 0.8 micro M.). Therapeutic concentrations of digoxin (2 nM.) also inhibited relaxation induced by acetylcholine and electrical field stimulation, which release nitric oxide from corpus cavernosum endothelial cells and nonadrenergic noncholinergic nerves, respectively. In vivo digoxin diminished penile rigidity during visual sexual stimulation and nocturnal penile tumescence testing compared to placebo without influencing libido or serum testosterone, estrogen or luteinizing hormone levels. Conclusions: Digoxin associated alteration of human erectile function may be explained, in part, by inhibition of corporeal smooth muscle sodium pump activity, which promotes contraction and impedes nitric oxide induced relaxation. Such findings suggest therapeutic use of digoxin for treatment of recurrent priapism states. References 1 : Physiology of erection and pharmacological management of impotence. J. Urol.1987; 137: 829. Link, Google Scholar 2 NIH Consensus Conference: Impotence. NIH Consensus Development Panel on Impotence. J.A.M.A.1993; 270: 83. Google Scholar 3 : Impotence. New Engl. J. Med.1989; 321: 1648. Google Scholar 4 : Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J. Urol.1994; 151: 54. Abstract, Google Scholar 5 : Drug-induced male sexual dysfunction. An update. Drug Safety1993; 8: 414. Google Scholar 6 : The effect of digoxin on mortality and morbidity in patients with heart failure. New Engl. J. Med.1997; 336: 525. Google Scholar 7 : Psychiatric side effects associated with the ten most commonly dispensed prescription drugs: a review. J. Fam. Pract.1991; 33: 177. Google Scholar 8 : Construction of a surrogate variable for impotence in the Massachusetts Male Aging Study. J. Clin. Epidemiol.1994; 47: 457. Google Scholar 9 : Subjective assessment of sexual dysfunction of patients on long-term administration of digoxin. Arch. Sex. Behav.1980; 9: 319. Google Scholar 10 : Digoxin and abnormal serum hormone levels. J.A.M.A.1973; 225: 1643. Google Scholar 11 : The effect of long-term administration of digoxin on plasma androgens and sexual dysfunction. J. Sex Mar. Ther.1987; 13: 58. Google Scholar 12 : Digoxin does not alter plasma steroid levels in healthy men. Clin. Pharmacol. Ther.1982; 32: 12. Google Scholar 13 : No effect of digitalis on sex and adrenal hormones in healthy subjects and in patients with congestive heart failure. Klin. Wochenschr.1984; 62: 65. Google Scholar 14 : Evaluation of hypothalamus-pituitary effects of digoxin. J. Clin. Pharmacol.1984; 24: 474. Google Scholar 15 : Possible involvement of cardiac Na+-K+-adenosine triphosphatase in the mechanism of action of cardiac glycosides. J. Pharmacol. Exp. Ther.1969; 168: 31. Google Scholar 16 : Physiological effects of endogenous ouabain: control of intracellular Ca2+ stores and cell responsiveness. Amer. J. Physiol.1993; 232: C165. Google Scholar 17 : Possible role of Na+-K+-Atpase in the regulation of human corpus cavernosum smooth muscle contractility by nitric oxide. Brit. J. Pharmacol.1995; 116: 2201. Google Scholar 18 : Stimulation of vascular Na+-K+ ATPase activity by nitric oxide: a cGMP independent effect. Amer. J. Physiol.1994; 266: H2146. Google Scholar 19 : Is ouabain-sensitive rubidium or potassium uptake a measure of sodium pump activity in isolated cardiac muscle?. Biochim. Biophys. Acta.1981; 640: 779. Google Scholar 20 : Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. New Engl. J. Med.1989; 320: 1025. Google Scholar 21 : Nocturnal penile tumescence. Urol. Clin. N. Amer.1988; 15: 81. Google Scholar 22 : Comparison of Rigiscan and formal nocturnal penile tumescence testing in the evaluation of erectile rigidity. J. Urol.1993; 149: 1265. Link, Google Scholar 23 : Comparison of Rigiscan and sleep laboratory nocturnal penile tumescence in the diagnosis of organic impotence. J. Urol.1995; 154: 1740. Link, Google Scholar 24 : Digitalis and allied cardiac glycosides. In: The Pharmacological Basis of Therapeutics. Edited by . New York: Pergamon Press, Inc.1990: 814. Google Scholar 25 : A Nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile occurs cavernosum smooth muscle. J. Clin. Invest.1991; 88: 112. Google Scholar 26 : Endothelium-derived nitric oxide and cyclo-oxygenase products modulate corpus cavernosum smooth muscle tone. J. Urol.1992; 147: 220. Abstract, Google Scholar 27 : Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. New Engl. J. Med.1992; 326: 90. Google Scholar 28 : Endothelium-dependent inhibition of Na+-K+-ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J. Clin. Invest.1992; 90: 727. Google Scholar 29 : Endothelium-dependent relaxation to acetylcholine in the rabbit basilar artery: importance of membrane hyperpolarization. Brit. J. Pharmacol.1992; 106: 143. Google Scholar 30 : Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature1990; 346: 69. Google Scholar 31 : Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature1994; 368: 850. Google Scholar 32 : Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Brit. J. Pharmacol.1988; 93: 515. Google Scholar 33 : Interaction between Na+, K+ exchanges and the direct inhibitory effect of acetylcholine on canine femoral arteries. Circ. Res.1980; 46: 826. Google Scholar 34 : Diminished arterial smooth muscle response to sodium nitroprusside during Na-K pump inhibition. Pharmacology1984; 28: 95. Google Scholar 35 : Effects of sodium-potassium pump inhibitors and membrane depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circ. Res.1985; 57: 164. Google Scholar 36 : Regional differentiation in rat aorta L-arginine metabolism and cGMP content in vitro. Amer. J. Physiol.1994; 266: H2287. Google Scholar 37 : Does a common mechanism induce the diverse complications of diabetes?. Diabetes1987; 36: 396. Google Scholar 38 : Cellular sodium transport in essential hypertension. New Engl. J. Med.1986; 314: 222. Google Scholar 39 : Diabetes decreases Na+-K+-pump concentration in skeletal muscles, heart ventricular muscle, and peripheral nerves of rat. Diabetes1987; 36: 842. Google Scholar 40 : Insulin resistance is associated with high plasma ouabain-like immunoreactivity concentration in NIDDM. Diabetologia1995; 38: 792. Google Scholar 41 : Recurrent prolonged erections and priapism as a sequala of priapism: pathophysiology and management. J. Urol.1991; 145: 764. Abstract, Google Scholar 42 : Treatment of recurrent veno-occlusive priapism by digoxin. J. Urol.1997; 157: 202. part 2, abstract 787. Google Scholar From the Department of Urology, Boston University School of Medicine, Boston, Massachusetts.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMONTAGUE D, JAROW J, BRODERICK G, DMOCHOWSKI R, HEATON J, LUE T, NEHRA A and SHARLIP I (2018) American Urological Association Guideline On The Management of PriapismJournal of Urology, VOL. 170, NO. 4 Part 1, (1318-1324), Online publication date: 1-Oct-2003.ROURKE K, FISCHLER A and JORDAN G (2018) Treatment of Recurrent Idiopathic Priapism With Oral BaclofenJournal of Urology, VOL. 168, NO. 6, (2552-2553), Online publication date: 1-Dec-2002. Volume 159Issue 5May 1998Page: 1529-1536 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information SANDEEP GUPTA (GUPTA) Recipient of the NIH Basic Science Cardiovascular Training Grant T 32 HL07224-19. Current address: Division of Urology, University of Pennsylvania School of Medicine, 3400 Spruce St., Philadelphia, Pennsylvania 19104-4283. More articles by this author PEDRAM SALIMPOUR More articles by this author INIGO SAENZ DE TEJADA More articles by this author JENNIFER DALEY More articles by this author SHAHRAM GHOLAMI More articles by this author MEIR DALLER More articles by this author ROBERT J. KRANE More articles by this author ABDUL M. TRAISH More articles by this author IRWIN GOLDSTEIN More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W1975060133 title "A POSSIBLE MECHANISM FOR ALTERATION OF HUMAN ERECTILE FUNCTION BY DIGOXIN: INHIBITION OF CORPUS CAVERNOSUM SODIUM/POTASSIUM ADENOSINE TRIPHOSPHATASE ACTIVITY" @default.
• W1975060133 cites W2000480225 @default.
• W1975060133 cites W2003328261 @default.
• W1975060133 cites W2012365138 @default.
• W1975060133 cites W2013333310 @default.
• W1975060133 cites W2014188915 @default.
• W1975060133 cites W2021783313 @default.
• W1975060133 cites W2022901952 @default.
• W1975060133 cites W2026279570 @default.
• W1975060133 cites W2044717069 @default.
• W1975060133 cites W2045786025 @default.
• W1975060133 cites W2056147576 @default.
• W1975060133 cites W2063503589 @default.
• W1975060133 cites W2066263460 @default.
• W1975060133 cites W2072091469 @default.
• W1975060133 cites W2073990575 @default.
• W1975060133 cites W2090075969 @default.
• W1975060133 cites W2090942139 @default.
• W1975060133 cites W2094797078 @default.
• W1975060133 cites W2111735429 @default.
• W1975060133 cites W2121020585 @default.
• W1975060133 cites W2123095186 @default.
• W1975060133 cites W2123744498 @default.
• W1975060133 cites W2131112785 @default.
• W1975060133 cites W2237035005 @default.
• W1975060133 cites W2297358297 @default.
• W1975060133 cites W2332297720 @default.
• W1975060133 cites W2399192164 @default.
• W1975060133 cites W2405116268 @default.
• W1975060133 cites W24186431 @default.
• W1975060133 cites W2945068164 @default.
• W1975060133 cites W42268303 @default.
• W1975060133 cites W4230764065 @default.
• W1975060133 cites W4231303923 @default.
• W1975060133 cites W4232133526 @default.
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