Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975083584> ?p ?o ?g. }
- W1975083584 endingPage "1017" @default.
- W1975083584 startingPage "997" @default.
- W1975083584 abstract "Tens of millions of patients are affected by liver disease worldwide. Many of these patients can benefit from cell therapy involving living metabolically active cells, either by treatment of their liver disease, or by prevention of their disease phenotype. Cell therapies, including hepatocyte transplantation and bioartificial liver (BAL) devices, have been proposed as therapeutic alternatives to the shortage of transplantable livers. Both BAL and hepatocyte transplantation are cellular therapies that avoid use of a whole liver. Hepatocytes are also widely used in drug screening and liver disease modelling. However, the demand for human hepatocytes, heavily outweighs their availability by conventional means. Induced pluripotent stem cells (iPSCs) technology brings together the potential benefits of embryonic stem cells (ESCs) (i.e., self-renewal, pluripotency) and addresses the major ethical and scientific concerns of ESCs: embryo destruction and immune-incompatibility. It has been shown that hepatocyte-like cells (HLCs) can be generated from iPSCs. Furthermore, human iPSCs (hiPSCs) can provide an unlimited source of human hepatocytes and hold great promise for applications in regenerative medicine, drug screening and liver diseases modelling. Despite steady progress, there are still several major obstacles that need to be overcome before iPSCs will reach the bedside. This review will focus on the current state of efforts to derive hiPSCs for potential use in modelling and treatment of liver disease." @default.
- W1975083584 created "2016-06-24" @default.
- W1975083584 creator A5033311876 @default.
- W1975083584 creator A5049816813 @default.
- W1975083584 creator A5087253610 @default.
- W1975083584 date "2014-09-05" @default.
- W1975083584 modified "2023-09-30" @default.
- W1975083584 title "Potential and Challenges of Induced Pluripotent Stem Cells in Liver Diseases Treatment" @default.
- W1975083584 cites W1483496013 @default.
- W1975083584 cites W1551735104 @default.
- W1975083584 cites W1969001620 @default.
- W1975083584 cites W1975373836 @default.
- W1975083584 cites W1979686921 @default.
- W1975083584 cites W1980247655 @default.
- W1975083584 cites W1980952042 @default.
- W1975083584 cites W1983810137 @default.
- W1975083584 cites W1984582197 @default.
- W1975083584 cites W1985842788 @default.
- W1975083584 cites W1986338679 @default.
- W1975083584 cites W1988627620 @default.
- W1975083584 cites W1990570289 @default.
- W1975083584 cites W1992676108 @default.
- W1975083584 cites W1993623398 @default.
- W1975083584 cites W1999566185 @default.
- W1975083584 cites W2000151960 @default.
- W1975083584 cites W2000653343 @default.
- W1975083584 cites W2001731899 @default.
- W1975083584 cites W2009222736 @default.
- W1975083584 cites W2012552985 @default.
- W1975083584 cites W2013195094 @default.
- W1975083584 cites W2019278990 @default.
- W1975083584 cites W2020695160 @default.
- W1975083584 cites W2020755558 @default.
- W1975083584 cites W2020886306 @default.
- W1975083584 cites W2028401005 @default.
- W1975083584 cites W2032279519 @default.
- W1975083584 cites W2042200929 @default.
- W1975083584 cites W2044046384 @default.
- W1975083584 cites W2051935450 @default.
- W1975083584 cites W2054275452 @default.
- W1975083584 cites W2057235969 @default.
- W1975083584 cites W2060244901 @default.
- W1975083584 cites W2065935807 @default.
- W1975083584 cites W2066558511 @default.
- W1975083584 cites W2069882108 @default.
- W1975083584 cites W2071393490 @default.
- W1975083584 cites W2071628173 @default.
- W1975083584 cites W2072715165 @default.
- W1975083584 cites W2076486071 @default.
- W1975083584 cites W2077806591 @default.
- W1975083584 cites W2079608885 @default.
- W1975083584 cites W2082829275 @default.
- W1975083584 cites W2086468676 @default.
- W1975083584 cites W2089338956 @default.
- W1975083584 cites W2094689158 @default.
- W1975083584 cites W2101634482 @default.
- W1975083584 cites W2103259382 @default.
- W1975083584 cites W2104108795 @default.
- W1975083584 cites W2105782901 @default.
- W1975083584 cites W2114190644 @default.
- W1975083584 cites W2118870321 @default.
- W1975083584 cites W2123128269 @default.
- W1975083584 cites W2123417462 @default.
- W1975083584 cites W2129567619 @default.
- W1975083584 cites W2129657985 @default.
- W1975083584 cites W2134319051 @default.
- W1975083584 cites W2137031333 @default.
- W1975083584 cites W2137658602 @default.
- W1975083584 cites W2143190548 @default.
- W1975083584 cites W2143445671 @default.
- W1975083584 cites W2145713912 @default.
- W1975083584 cites W2146776134 @default.
- W1975083584 cites W2157645703 @default.
- W1975083584 cites W2159416713 @default.
- W1975083584 cites W2160050713 @default.
- W1975083584 cites W2160139458 @default.
- W1975083584 cites W2161301993 @default.
- W1975083584 cites W2162340412 @default.
- W1975083584 cites W2162807448 @default.
- W1975083584 cites W2168967248 @default.
- W1975083584 doi "https://doi.org/10.3390/jcm3030997" @default.
- W1975083584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4449640" @default.
- W1975083584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26237490" @default.
- W1975083584 hasPublicationYear "2014" @default.
- W1975083584 type Work @default.
- W1975083584 sameAs 1975083584 @default.
- W1975083584 citedByCount "24" @default.
- W1975083584 countsByYear W19750835842016 @default.
- W1975083584 countsByYear W19750835842017 @default.
- W1975083584 countsByYear W19750835842018 @default.
- W1975083584 countsByYear W19750835842019 @default.
- W1975083584 countsByYear W19750835842020 @default.
- W1975083584 countsByYear W19750835842021 @default.
- W1975083584 countsByYear W19750835842023 @default.
- W1975083584 crossrefType "journal-article" @default.
- W1975083584 hasAuthorship W1975083584A5033311876 @default.
- W1975083584 hasAuthorship W1975083584A5049816813 @default.
- W1975083584 hasAuthorship W1975083584A5087253610 @default.