FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975092967> ?p ?o ?g. }

• W1975092967 endingPage "202" @default.
• W1975092967 startingPage "191" @default.
• W1975092967 abstract "Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) are major pathogenic factors in peptic ulcer disease but whether these two factors exert synergistic or antagonistic effects on ulcer healing has been a subject of controversy. We compared the effect of aspirin alone with that of aspirin combined with H. pylori on gastric acid secretion and healing of acetic acid gastric ulcers in rats. The H. pylori colonization of gastric mucosa was determined by viable H. pylori culture, histology and assessment of bacterial DNA using polymerase chain reaction (PCR). The area of ulcers, gastric blood flow, mucosal generation of prostaglandin E(2) and plasma gastrin levels and expression of cyclooxygenase-1, cyclooxygenase-2 and growth factors was determined. Aspirin delayed significantly the healing of chronic gastric ulcers, decreased the gastric blood flow at the ulcer margin and gastric mucosal prostaglandin E(2) generation being without significant influence on gastric acid output. H. pylori acquisition that produced moderate gastric inflammation at the ulcer margin delayed significantly the healing of gastric ulcers, decreased significantly both the gastric blood flow at the ulcer margin and the gastric secretion while raising significantly the gastric mucosal prostaglandin E(2) generation and plasma gastrin levels. H. pylori infection attenuated the aspirin-induced inhibition of ulcer healing and accompanying fall in the gastric blood flow. Both aspirin and H. pylori up-regulated significantly cyclooxygenase-2 messenger RNA (mRNA) and protein but not that of cyclooxygenase-1 at the ulcer margin. Aspirin reduced significantly the transforming growth factor alpha- and vascular endothelial growth factor mRNAs, but these effects were significantly attenuated by H. pylori. We conclude that H. pylori antagonizes, in part, aspirin-induced delay of ulcer healing due to suppression of acid secretion, the enhancement in prostaglandin E(2) possibly derived from cyclooxygenase-2 and the overexpression of transforming growth factor alpha and vascular endothelial growth factor in the ulcer area." @default.
• W1975092967 created "2016-06-24" @default.
• W1975092967 creator A5026040870 @default.
• W1975092967 creator A5045493260 @default.
• W1975092967 creator A5053500142 @default.
• W1975092967 creator A5067941526 @default.
• W1975092967 creator A5068128072 @default.
• W1975092967 creator A5075086617 @default.
• W1975092967 creator A5086959830 @default.
• W1975092967 creator A5087690868 @default.
• W1975092967 creator A5090892875 @default.
• W1975092967 date "2002-09-01" @default.
• W1975092967 modified "2023-10-12" @default.
• W1975092967 title "Effect of Helicobacter pylori on delay in ulcer healing induced by aspirin in rats" @default.
• W1975092967 cites W1498600389 @default.
• W1975092967 cites W1893182679 @default.
• W1975092967 cites W1964542714 @default.
• W1975092967 cites W1965651169 @default.
• W1975092967 cites W1966311109 @default.
• W1975092967 cites W1968609884 @default.
• W1975092967 cites W1973505027 @default.
• W1975092967 cites W1983621857 @default.
• W1975092967 cites W1999433734 @default.
• W1975092967 cites W2009366732 @default.
• W1975092967 cites W2010332507 @default.
• W1975092967 cites W2019709974 @default.
• W1975092967 cites W2025836972 @default.
• W1975092967 cites W2027288643 @default.
• W1975092967 cites W2057151830 @default.
• W1975092967 cites W2060782441 @default.
• W1975092967 cites W2067007327 @default.
• W1975092967 cites W2069539829 @default.
• W1975092967 cites W2079029298 @default.
• W1975092967 cites W2105811856 @default.
• W1975092967 cites W2128557023 @default.
• W1975092967 cites W2141046053 @default.
• W1975092967 cites W2143548707 @default.
• W1975092967 cites W2148798285 @default.
• W1975092967 cites W2149933060 @default.
• W1975092967 cites W2151661497 @default.
• W1975092967 cites W2157782064 @default.
• W1975092967 cites W2161320631 @default.
• W1975092967 cites W2165368238 @default.
• W1975092967 cites W2948387191 @default.
• W1975092967 cites W4234210346 @default.
• W1975092967 cites W4294216491 @default.
• W1975092967 doi "https://doi.org/10.1016/s0014-2999(02)02250-1" @default.
• W1975092967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12231391" @default.
• W1975092967 hasPublicationYear "2002" @default.
• W1975092967 type Work @default.
• W1975092967 sameAs 1975092967 @default.
• W1975092967 citedByCount "12" @default.
• W1975092967 countsByYear W19750929672012 @default.
• W1975092967 countsByYear W19750929672014 @default.
• W1975092967 countsByYear W19750929672023 @default.
• W1975092967 crossrefType "journal-article" @default.
• W1975092967 hasAuthorship W1975092967A5026040870 @default.
• W1975092967 hasAuthorship W1975092967A5045493260 @default.
• W1975092967 hasAuthorship W1975092967A5053500142 @default.
• W1975092967 hasAuthorship W1975092967A5067941526 @default.
• W1975092967 hasAuthorship W1975092967A5068128072 @default.
• W1975092967 hasAuthorship W1975092967A5075086617 @default.
• W1975092967 hasAuthorship W1975092967A5086959830 @default.
• W1975092967 hasAuthorship W1975092967A5087690868 @default.
• W1975092967 hasAuthorship W1975092967A5090892875 @default.
• W1975092967 hasConcept C126322002 @default.
• W1975092967 hasConcept C181199279 @default.
• W1975092967 hasConcept C185592680 @default.
• W1975092967 hasConcept C2776409635 @default.
• W1975092967 hasConcept C2776914184 @default.
• W1975092967 hasConcept C2776986829 @default.
• W1975092967 hasConcept C2777504413 @default.
• W1975092967 hasConcept C2777628954 @default.
• W1975092967 hasConcept C2777956040 @default.
• W1975092967 hasConcept C2778677798 @default.
• W1975092967 hasConcept C2779422922 @default.
• W1975092967 hasConcept C2779689624 @default.
• W1975092967 hasConcept C2780664492 @default.
• W1975092967 hasConcept C2781443798 @default.
• W1975092967 hasConcept C49039625 @default.
• W1975092967 hasConcept C55493867 @default.
• W1975092967 hasConcept C71924100 @default.
• W1975092967 hasConcept C90924648 @default.
• W1975092967 hasConceptScore W1975092967C126322002 @default.
• W1975092967 hasConceptScore W1975092967C181199279 @default.
• W1975092967 hasConceptScore W1975092967C185592680 @default.
• W1975092967 hasConceptScore W1975092967C2776409635 @default.
• W1975092967 hasConceptScore W1975092967C2776914184 @default.
• W1975092967 hasConceptScore W1975092967C2776986829 @default.
• W1975092967 hasConceptScore W1975092967C2777504413 @default.
• W1975092967 hasConceptScore W1975092967C2777628954 @default.
• W1975092967 hasConceptScore W1975092967C2777956040 @default.
• W1975092967 hasConceptScore W1975092967C2778677798 @default.
• W1975092967 hasConceptScore W1975092967C2779422922 @default.
• W1975092967 hasConceptScore W1975092967C2779689624 @default.
• W1975092967 hasConceptScore W1975092967C2780664492 @default.
• W1975092967 hasConceptScore W1975092967C2781443798 @default.
• W1975092967 hasConceptScore W1975092967C49039625 @default.

• next