Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975101821> ?p ?o ?g. }
- W1975101821 endingPage "382" @default.
- W1975101821 startingPage "373" @default.
- W1975101821 abstract "In the present study, we have examined the expression of anaphylatoxin C3a and C5a receptors (C3aR and C5aR) at the mRNA and protein levels in ischemic brain tissues following permanent middle cerebral artery (MCA) occlusion in the mouse. C3aR and C5aR mRNAs were both detected by semiquantitative reverse transcription and polymerase chain reaction (RT-PCR) and the cellular distribution of each receptor was analyzed by immunohistochemistry. Significant increases in the expression of C3aR and C5aR mRNAs in the ischemic cortex were observed; the expression of both reached a peak at 2 days after MCA occlusion (4.3- and 3.4-fold increases, respectively, compared with nonoperated control cortical samples; P < 0.00625 with Bonferroni's correction, n = 3). C3aR and C5aR stainings were found constitutively on neurons and astrocytes. In ischemic tissues, we observed that C3aR and C5aR were expressed de novo on endothelial cells of blood vessels, at 6 h and 2 days after MCA occlusion, respectively. C3aR and C5aR immunostaining was increased in macrophage-like cells and reactive astrocytes 7 days postocclusion. C3a and C5a may play an important role in promoting inflammatory and/or repair processes in the ischemic brain by regulating glial cell activation and chemotaxis." @default.
- W1975101821 created "2016-06-24" @default.
- W1975101821 creator A5020921085 @default.
- W1975101821 creator A5028934517 @default.
- W1975101821 creator A5040108125 @default.
- W1975101821 creator A5042200772 @default.
- W1975101821 creator A5044263958 @default.
- W1975101821 creator A5075317082 @default.
- W1975101821 creator A5079875656 @default.
- W1975101821 date "2000-01-01" @default.
- W1975101821 modified "2023-10-18" @default.
- W1975101821 title "Expression of Receptors for Complement Anaphylatoxins C3a and C5a Following Permanent Focal Cerebral Ischemia in the Mouse" @default.
- W1975101821 cites W1511644085 @default.
- W1975101821 cites W1538305637 @default.
- W1975101821 cites W1567432487 @default.
- W1975101821 cites W1584856024 @default.
- W1975101821 cites W1684253917 @default.
- W1975101821 cites W1800839404 @default.
- W1975101821 cites W1867704897 @default.
- W1975101821 cites W1930803389 @default.
- W1975101821 cites W1969129517 @default.
- W1975101821 cites W1976086769 @default.
- W1975101821 cites W1979961027 @default.
- W1975101821 cites W1983612328 @default.
- W1975101821 cites W1986428075 @default.
- W1975101821 cites W2001870721 @default.
- W1975101821 cites W2004514472 @default.
- W1975101821 cites W2007045381 @default.
- W1975101821 cites W2012228544 @default.
- W1975101821 cites W2018269249 @default.
- W1975101821 cites W2020511908 @default.
- W1975101821 cites W2025959962 @default.
- W1975101821 cites W2032172950 @default.
- W1975101821 cites W2034425798 @default.
- W1975101821 cites W2035396253 @default.
- W1975101821 cites W2040957577 @default.
- W1975101821 cites W2045703222 @default.
- W1975101821 cites W2046335509 @default.
- W1975101821 cites W2055813216 @default.
- W1975101821 cites W2059502318 @default.
- W1975101821 cites W2063842801 @default.
- W1975101821 cites W2075154733 @default.
- W1975101821 cites W2077531002 @default.
- W1975101821 cites W2080135373 @default.
- W1975101821 cites W2083200309 @default.
- W1975101821 cites W2091021171 @default.
- W1975101821 cites W2094749887 @default.
- W1975101821 cites W2097361537 @default.
- W1975101821 cites W2099233769 @default.
- W1975101821 cites W2104371820 @default.
- W1975101821 cites W2106949710 @default.
- W1975101821 cites W2132426657 @default.
- W1975101821 cites W2134435275 @default.
- W1975101821 cites W2137655472 @default.
- W1975101821 cites W2150842023 @default.
- W1975101821 cites W2159154575 @default.
- W1975101821 doi "https://doi.org/10.1006/exnr.1999.7273" @default.
- W1975101821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10683302" @default.
- W1975101821 hasPublicationYear "2000" @default.
- W1975101821 type Work @default.
- W1975101821 sameAs 1975101821 @default.
- W1975101821 citedByCount "138" @default.
- W1975101821 countsByYear W19751018212012 @default.
- W1975101821 countsByYear W19751018212013 @default.
- W1975101821 countsByYear W19751018212014 @default.
- W1975101821 countsByYear W19751018212015 @default.
- W1975101821 countsByYear W19751018212016 @default.
- W1975101821 countsByYear W19751018212017 @default.
- W1975101821 countsByYear W19751018212018 @default.
- W1975101821 countsByYear W19751018212019 @default.
- W1975101821 countsByYear W19751018212020 @default.
- W1975101821 countsByYear W19751018212021 @default.
- W1975101821 countsByYear W19751018212022 @default.
- W1975101821 countsByYear W19751018212023 @default.
- W1975101821 crossrefType "journal-article" @default.
- W1975101821 hasAuthorship W1975101821A5020921085 @default.
- W1975101821 hasAuthorship W1975101821A5028934517 @default.
- W1975101821 hasAuthorship W1975101821A5040108125 @default.
- W1975101821 hasAuthorship W1975101821A5042200772 @default.
- W1975101821 hasAuthorship W1975101821A5044263958 @default.
- W1975101821 hasAuthorship W1975101821A5075317082 @default.
- W1975101821 hasAuthorship W1975101821A5079875656 @default.
- W1975101821 hasConcept C111684460 @default.
- W1975101821 hasConcept C126322002 @default.
- W1975101821 hasConcept C142724271 @default.
- W1975101821 hasConcept C170493617 @default.
- W1975101821 hasConcept C203014093 @default.
- W1975101821 hasConcept C204232928 @default.
- W1975101821 hasConcept C2775841333 @default.
- W1975101821 hasConcept C2776914184 @default.
- W1975101821 hasConcept C4224716 @default.
- W1975101821 hasConcept C541997718 @default.
- W1975101821 hasConcept C71924100 @default.
- W1975101821 hasConcept C86803240 @default.
- W1975101821 hasConcept C8891405 @default.
- W1975101821 hasConcept C90582226 @default.
- W1975101821 hasConceptScore W1975101821C111684460 @default.
- W1975101821 hasConceptScore W1975101821C126322002 @default.