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- W1975124798 abstract "The pH sensitivity of benzodiazepine binding suggests that a histidine residue may be present in, or close to the benzodiazepine binding site. This was confirmed by the selective modification of histidine residues using diethyl pyrocarbonate which was found to block both benzodiazepine and beta-carboline binding. In order to assess whether this histidine residue is located in or adjacent to the benzodiazepine and beta-carboline binding sites, experiments were performed using either benzodiazepine or beta-carboline to protect against diethyl pyrocarbonate treatment. It was found that benzodiazepine agonists, but not propyl beta-carboline protect the benzodiazepine binding sites from diethyl pyrocarbonate modification." @default.
- W1975124798 created "2016-06-24" @default.
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- W1975124798 creator A5057419092 @default.
- W1975124798 date "1987-07-27" @default.
- W1975124798 modified "2023-09-25" @default.
- W1975124798 title "Benzodiazepine agonists protect a histidine residue from modification by diethyl pyrocarbonate whereas propyl β-carboline does not" @default.
- W1975124798 cites W1980969475 @default.
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- W1975124798 doi "https://doi.org/10.1016/0014-5793(87)80240-5" @default.
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- W1975124798 hasPublicationYear "1987" @default.
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