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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975127012> ?p ?o ?g. }

• W1975127012 endingPage "737" @default.
• W1975127012 startingPage "727" @default.
• W1975127012 abstract "Acquisition of functional Na+ channels is a critical event in the development of a neuron because it allows the generation of conducted action potentials. alpha subunit mRNA is first detected in developing rat retina at 1% of its maximum level on embryonic day 15, 4 days after the first ganglion cells are formed. alpha subunit protein is detected in the axons of the ganglion cells at this time, but beta 1 subunits, beta 2 subunits, and high affinity saxitoxin binding sites are not detected until after birth. There is an approximately coordinate increase in alpha subunit mRNA, alpha, beta 1, and beta 2 subunit protein, assembled complexes of alpha, beta 1, and beta 2 subunits, and high affinity saxitoxin binding sites between postnatal days 7 and 21. Expression of alpha subunit genes is an early event in ganglion cell differentiation, and both gene transcription and posttranslational assembly are separate, rate-limiting steps in development of Na+ channels." @default.
• W1975127012 created "2016-06-24" @default.
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• W1975127012 date "1988-10-01" @default.
• W1975127012 modified "2023-09-26" @default.
• W1975127012 title "Sodium channel expression and assembly during development of retinal ganglion cells" @default.
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• W1975127012 doi "https://doi.org/10.1016/0896-6273(88)90171-7" @default.
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