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- W1975134653 abstract "Type 2 diabetes mellitus with hyperinsulinaemia is a state of sympathetic nerve hyperactivity, which can develop subsequently in non-diabetic first-degree offspring of patients with type 2 diabetes. Although both type 2 diabetes and sympathetic activation are major cardiovascular risk factors, the level of sympathetic nerve activity is as yet unknown in offspring of type 2 diabetic patients who are ostensibly normal. We therefore sought to quantify sympathetic nerve activity and its relationship to plasma insulin levels in ostensibly normal offspring of patients with type 2 diabetes, relative to a matched normal control group with no family history of type 2 diabetes.In two closely matched groups comprising 23 non-diabetic offspring of type 2 diabetic patients and 23 normal control individuals we measured resting muscle sympathetic nerve activity (MSNA) as the mean frequency of multi-unit bursts of MSNA and single units of MSNA (s-MSNA) with defined vasoconstrictor properties.In offspring of type 2 diabetic patients, the fasting plasma levels of insulin (7.4+/-0.80 microU/ml) and s-MSNA (45+/-3.2 impulses/100 beats) were greater (p<0.009 and p<0.003) than those in control persons (4.6+/-0.76 microU/ml and 32+/-3.1 impulses/100 beats, respectively). MSNA bursts and derived insulin resistance followed similar trends. Sympathetic nerve activity was significantly correlated to insulin levels (p<0.0002) and resistance (p<0.0001) in offspring of type 2 diabetic patients, but not in control subjects.Sympathetic activation occurred in normal non-diabetic offspring of patients with type 2 diabetes in proportion to their plasma insulin levels. Our data indicate the presence of a mechanistic link between hyperinsulinaemia and sympathetic activation, both of which could play a role in the subsequent development of cardiovascular risk factors." @default.
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- W1975134653 date "2006-09-13" @default.
- W1975134653 modified "2023-10-08" @default.
- W1975134653 title "Sympathetic nerve hyperactivity in non-diabetic offspring of patients with type 2 diabetes mellitus" @default.
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- W1975134653 doi "https://doi.org/10.1007/s00125-006-0399-9" @default.
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