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- W1975138565 abstract "ObjectivesAttempts to localize the source of epileptic activity by linking electroencephalographic (EEG) abnormalities to blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) signal alterations are hampered mainly by EEG distortions during MRI, subject motion, and unknown hemodynamic response characteristics. MethodsUsing T2*-weighted echo-planar imaging at 2.0 T (2 s temporal resolution, 2 × 2 × 4 mm(3) spatial resolution), this work demonstrates strategies to alleviate some of these problems while studying a patient who had idiopathic generalized epilepsy with poly-spike and slow-wave complexes. ResultsContinuous EEG recordings during dynamic MRI (500 ms scanning, 1500 ms delay) and post-examination derivation of an EEG reference function for MRI analysis revealed positive BOLD MRI responses with temporal characteristics similar to those obtained for functional challenges. ConclusionsThe ability to map focal epileptic activity and/or associated cognitive processing provides new potential for both epilepsy research and clinical patient management.Spatio-Temporal Imaging of Focal Interictal Epileptiform Activity Using EEG-Triggered Functional MRIKrakow K, Lemieux L, Messina D, Scott CA, Symms MR, Duncan JS, Fish DREpileptic Disord 2001;3:67–74EEG-triggered, blood oxygen level-dependent functional MRI (BOLD-fMRI) was used in 24 patients with localization-related epilepsy and frequent interictal epileptiform discharges (spikes) to identify those brain areas involved in generating the spikes, and to study the evolution of the BOLD signal change over time. The location of the fMRI activation was compared with the scalp EEG spike focus and the structural MR abnormality. Twelve patients (50%) had an fMRI activation concordant with the EEG focus and structural brain abnormalities where present (n = 7). In 2 other patients, the fMRI activation was non-concordant with electroclinical findings. The remaining 10 patients (41.7%) showed no significant fMRI activation. These patients had significantly lower mean spike amplitudes compared to those with positive fMRI results (p = 0.03). The time course of the BOLD response was studied in 3 patients and this revealed a maximum signal change 1.5 to 7.5 sec after the spike. In conclusion, EEG-triggered fMRI can directly identify the generators of interictal epileptiform activity, with high spatial resolution, in selected patients with frequent spikes. The superior spatial resolution obtainable through EEG-triggered fMRI may provide an additional non-invasive tool in the presurgical evaluation of patients with intractable focal seizures." @default.
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- W1975138565 date "2002-01-01" @default.
- W1975138565 modified "2023-09-25" @default.
- W1975138565 title "Functional MRI of Interictal EEG Activity" @default.
- W1975138565 doi "https://doi.org/10.1046/j.1535-7597.2002.00006.x" @default.
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