Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975142744> ?p ?o ?g. }
- W1975142744 endingPage "231" @default.
- W1975142744 startingPage "221" @default.
- W1975142744 abstract "Alu exonization, which is an evolutionary pathway that creates primate-specific transcriptomic diversity, is a powerful tool for studying alternative-splicing regulation. Through bioinformatic analyses combined with experimental methodology, we identified the mutational changes needed to create functional 5′ splice sites in Alu. We revealed a complex mechanism by which the sequence composition of the 5′ splice site and its base pairing with the small nuclear RNA U1 govern alternative splicing. We show that in Alu-derived GC introns the strength of the base pairing between U1 snRNA and the 5′ splice site controls the skipping/inclusion ratio of alternative splicing. Based on these findings, we identified 7810 Alus within the human genome that are prone to exonization. Mutations in these Alus may cause genetic disorders or contribute to human-specific protein diversity." @default.
- W1975142744 created "2016-06-24" @default.
- W1975142744 creator A5004587704 @default.
- W1975142744 creator A5023936064 @default.
- W1975142744 creator A5024718393 @default.
- W1975142744 creator A5029261997 @default.
- W1975142744 creator A5047175745 @default.
- W1975142744 creator A5051730578 @default.
- W1975142744 creator A5084689088 @default.
- W1975142744 date "2004-04-01" @default.
- W1975142744 modified "2023-10-14" @default.
- W1975142744 title "Minimal Conditions for Exonization of Intronic Sequences" @default.
- W1975142744 cites W1786066781 @default.
- W1975142744 cites W1865233844 @default.
- W1975142744 cites W1965074434 @default.
- W1975142744 cites W1970774008 @default.
- W1975142744 cites W1978909865 @default.
- W1975142744 cites W1982650273 @default.
- W1975142744 cites W1983917564 @default.
- W1975142744 cites W1984502430 @default.
- W1975142744 cites W2001672954 @default.
- W1975142744 cites W2003060921 @default.
- W1975142744 cites W2006193162 @default.
- W1975142744 cites W2006276976 @default.
- W1975142744 cites W2008948977 @default.
- W1975142744 cites W2013340095 @default.
- W1975142744 cites W2017313617 @default.
- W1975142744 cites W2019654533 @default.
- W1975142744 cites W2021434409 @default.
- W1975142744 cites W2023927591 @default.
- W1975142744 cites W2024588724 @default.
- W1975142744 cites W2027011833 @default.
- W1975142744 cites W2027042879 @default.
- W1975142744 cites W2028279880 @default.
- W1975142744 cites W2033837701 @default.
- W1975142744 cites W2040637308 @default.
- W1975142744 cites W2048618925 @default.
- W1975142744 cites W2059366734 @default.
- W1975142744 cites W2063318299 @default.
- W1975142744 cites W2068514705 @default.
- W1975142744 cites W2071746055 @default.
- W1975142744 cites W2074002473 @default.
- W1975142744 cites W2077689651 @default.
- W1975142744 cites W2086739233 @default.
- W1975142744 cites W2088056125 @default.
- W1975142744 cites W2089465951 @default.
- W1975142744 cites W2090521141 @default.
- W1975142744 cites W2106882534 @default.
- W1975142744 cites W2107128703 @default.
- W1975142744 cites W2108247718 @default.
- W1975142744 cites W2115149771 @default.
- W1975142744 cites W2116911290 @default.
- W1975142744 cites W2118600301 @default.
- W1975142744 cites W2120744807 @default.
- W1975142744 cites W2134208113 @default.
- W1975142744 cites W2146528880 @default.
- W1975142744 cites W2151464048 @default.
- W1975142744 cites W2162396524 @default.
- W1975142744 cites W2165843546 @default.
- W1975142744 cites W2166187656 @default.
- W1975142744 cites W2166437079 @default.
- W1975142744 cites W2168909179 @default.
- W1975142744 cites W2909975970 @default.
- W1975142744 cites W4212855844 @default.
- W1975142744 cites W4243177766 @default.
- W1975142744 doi "https://doi.org/10.1016/s1097-2765(04)00181-9" @default.
- W1975142744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15099521" @default.
- W1975142744 hasPublicationYear "2004" @default.
- W1975142744 type Work @default.
- W1975142744 sameAs 1975142744 @default.
- W1975142744 citedByCount "156" @default.
- W1975142744 countsByYear W19751427442012 @default.
- W1975142744 countsByYear W19751427442013 @default.
- W1975142744 countsByYear W19751427442014 @default.
- W1975142744 countsByYear W19751427442015 @default.
- W1975142744 countsByYear W19751427442016 @default.
- W1975142744 countsByYear W19751427442018 @default.
- W1975142744 countsByYear W19751427442019 @default.
- W1975142744 countsByYear W19751427442020 @default.
- W1975142744 countsByYear W19751427442021 @default.
- W1975142744 countsByYear W19751427442022 @default.
- W1975142744 countsByYear W19751427442023 @default.
- W1975142744 crossrefType "journal-article" @default.
- W1975142744 hasAuthorship W1975142744A5004587704 @default.
- W1975142744 hasAuthorship W1975142744A5023936064 @default.
- W1975142744 hasAuthorship W1975142744A5024718393 @default.
- W1975142744 hasAuthorship W1975142744A5029261997 @default.
- W1975142744 hasAuthorship W1975142744A5047175745 @default.
- W1975142744 hasAuthorship W1975142744A5051730578 @default.
- W1975142744 hasAuthorship W1975142744A5084689088 @default.
- W1975142744 hasBestOaLocation W19751427441 @default.
- W1975142744 hasConcept C100299639 @default.
- W1975142744 hasConcept C104317684 @default.
- W1975142744 hasConcept C141231307 @default.
- W1975142744 hasConcept C194583182 @default.
- W1975142744 hasConcept C194993378 @default.
- W1975142744 hasConcept C197077220 @default.
- W1975142744 hasConcept C2780989783 @default.