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- W1975145684 abstract "Several mechanisms have been invoked to explain the increased liver triglyceride content induced in the rat by alcohol. It has been stated that alcohol promotes hepatic synthesis of triglyceride and increases hepatic α-glycerophosphate levels. Alcohol has also been shown to promote preferential incorporation of FFA into triglycerides rather than into phospholipids. Following an acute intoxicating dose of alcohol, excessive mobilization of FFA from adipose tissue has been documented by some observers. As it has been demonstrated that the drug CPIB causes an increase in liver phospholipid content and interferes with release of fatty acid and glycerol from adipose tissue, the effect of this drug was observed in the rat on serum and liver lipid changes induced by alcohol. A single oral dose of ethanol, 6 Gm./Kg., resulted in lower serum FFA levels, lower liver triglyceride levels, and higher liver phospholipid levels in rats pretreated for 2 weeks with CPIB as 0.25 per cent by weight of diet than in a matched group of animals receiving a normal diet. The liver triglyceride content was higher and the liver phospholipid content was lower in CPIB-treated rats given alcohol than in CPIB-treated rats fed glucose. Although modification by CPIB of the lipid changes induced by alcohol suggests that the drug may interfere with adipose tissue lipolysis, it is also possible that the effect of alcohol is modified following a direct effect of CPIB on hepatocellular function. No difference in adipose tissue lipoprotein lipase content was found in CPIB-treated and untreated animals 16 hours after glucose ingestion." @default.
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- W1975145684 date "1966-10-01" @default.
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- W1975145684 title "The effect of ethyl α-p. Chlorophenoxyisobutyrate on ethanol-induced hepatic steatosis in the rat" @default.
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- W1975145684 doi "https://doi.org/10.1016/0026-0495(66)90157-0" @default.
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