FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975149490> ?p ?o ?g. }

• W1975149490 endingPage "628" @default.
• W1975149490 startingPage "621" @default.
• W1975149490 abstract "Transforming growth factor-β (TGF-β)1, 2 and 3 peptide superfamily signaling is not only essential for both prenatal and postnatal lung morphogenesis, but also plays a key role in the pathobiology of bronchopulmonary dysplasia, pulmonary fibrosis and emphysema. The respective null mutations of TGF-β1 reveals its function to protect against lung inflammation, of TGF-β2 in cardiopulmonary morphogenesis and of TGF-β3 in lung and palatal fusion. TGF-β signal transduction is tightly regulated at all levels from ligand bioavailability in the extracellular space to the nucleus. Protease-antiprotease balance, correct final assembly of lung matrix and hence completion of alveolarization are all important normal functions of the TGF-β signaling pathway. The consequences of excess TGF-β signaling depend on the developmental stage of the lung: alveolar hypoplasia and fibrosis in the growing lung, fibrosis in the adult lung. While inflammation can induce excessive TGF-β signaling, lung fibrosis per se is inflammation independent and mediated by excessive TGF-β and Smad3 signaling. Therapeutic manipulation of TGF-β-Smad3 function is therefore a rational target. However, its application to pulmonary medicine will not be easy because of the narrow therapeutic range and many-layered physiological regulation of this pathway." @default.
• W1975149490 created "2016-06-24" @default.
• W1975149490 creator A5005295653 @default.
• W1975149490 creator A5042634877 @default.
• W1975149490 creator A5065730561 @default.
• W1975149490 creator A5079936447 @default.
• W1975149490 date "2008-01-01" @default.
• W1975149490 modified "2023-10-16" @default.
• W1975149490 title "Transforming Growth Factor-β Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema" @default.
• W1975149490 cites W1565561072 @default.
• W1975149490 cites W1586552615 @default.
• W1975149490 cites W1662007645 @default.
• W1975149490 cites W1834591308 @default.
• W1975149490 cites W1840439659 @default.
• W1975149490 cites W1967741390 @default.
• W1975149490 cites W1991082072 @default.
• W1975149490 cites W1993612982 @default.
• W1975149490 cites W1998975199 @default.
• W1975149490 cites W1999644843 @default.
• W1975149490 cites W2013575704 @default.
• W1975149490 cites W2019869369 @default.
• W1975149490 cites W2021517378 @default.
• W1975149490 cites W2043316572 @default.
• W1975149490 cites W2057967719 @default.
• W1975149490 cites W2060412699 @default.
• W1975149490 cites W2060928333 @default.
• W1975149490 cites W2066783658 @default.
• W1975149490 cites W2088519666 @default.
• W1975149490 cites W2094165314 @default.
• W1975149490 cites W2100880370 @default.
• W1975149490 cites W2104265411 @default.
• W1975149490 cites W2114154263 @default.
• W1975149490 cites W2122588714 @default.
• W1975149490 cites W2124887937 @default.
• W1975149490 cites W2136358097 @default.
• W1975149490 cites W2136592357 @default.
• W1975149490 cites W2145489141 @default.
• W1975149490 cites W2148738605 @default.
• W1975149490 cites W2151461937 @default.
• W1975149490 cites W2153078739 @default.
• W1975149490 cites W2163667608 @default.
• W1975149490 cites W2165392704 @default.
• W1975149490 cites W2170495797 @default.
• W1975149490 cites W2283610042 @default.
• W1975149490 cites W2416859301 @default.
• W1975149490 cites W4255779404 @default.
• W1975149490 cites W4296588288 @default.
• W1975149490 doi "https://doi.org/10.1007/978-1-59745-292-2_39" @default.
• W1975149490 hasPublicationYear "2008" @default.
• W1975149490 type Work @default.
• W1975149490 sameAs 1975149490 @default.
• W1975149490 citedByCount "0" @default.
• W1975149490 crossrefType "book-chapter" @default.
• W1975149490 hasAuthorship W1975149490A5005295653 @default.
• W1975149490 hasAuthorship W1975149490A5042634877 @default.
• W1975149490 hasAuthorship W1975149490A5065730561 @default.
• W1975149490 hasAuthorship W1975149490A5079936447 @default.
• W1975149490 hasConcept C118131993 @default.
• W1975149490 hasConcept C126322002 @default.
• W1975149490 hasConcept C142724271 @default.
• W1975149490 hasConcept C203014093 @default.
• W1975149490 hasConcept C2776914184 @default.
• W1975149490 hasConcept C2777714996 @default.
• W1975149490 hasConcept C2778229498 @default.
• W1975149490 hasConcept C2778376644 @default.
• W1975149490 hasConcept C2778721537 @default.
• W1975149490 hasConcept C2779234561 @default.
• W1975149490 hasConcept C2780559512 @default.
• W1975149490 hasConcept C2781244666 @default.
• W1975149490 hasConcept C502942594 @default.
• W1975149490 hasConcept C54355233 @default.
• W1975149490 hasConcept C62478195 @default.
• W1975149490 hasConcept C71924100 @default.
• W1975149490 hasConcept C86803240 @default.
• W1975149490 hasConcept C95444343 @default.
• W1975149490 hasConceptScore W1975149490C118131993 @default.
• W1975149490 hasConceptScore W1975149490C126322002 @default.
• W1975149490 hasConceptScore W1975149490C142724271 @default.
• W1975149490 hasConceptScore W1975149490C203014093 @default.
• W1975149490 hasConceptScore W1975149490C2776914184 @default.
• W1975149490 hasConceptScore W1975149490C2777714996 @default.
• W1975149490 hasConceptScore W1975149490C2778229498 @default.
• W1975149490 hasConceptScore W1975149490C2778376644 @default.
• W1975149490 hasConceptScore W1975149490C2778721537 @default.
• W1975149490 hasConceptScore W1975149490C2779234561 @default.
• W1975149490 hasConceptScore W1975149490C2780559512 @default.
• W1975149490 hasConceptScore W1975149490C2781244666 @default.
• W1975149490 hasConceptScore W1975149490C502942594 @default.
• W1975149490 hasConceptScore W1975149490C54355233 @default.
• W1975149490 hasConceptScore W1975149490C62478195 @default.
• W1975149490 hasConceptScore W1975149490C71924100 @default.
• W1975149490 hasConceptScore W1975149490C86803240 @default.
• W1975149490 hasConceptScore W1975149490C95444343 @default.
• W1975149490 hasLocation W19751494901 @default.
• W1975149490 hasOpenAccess W1975149490 @default.
• W1975149490 hasPrimaryLocation W19751494901 @default.
• W1975149490 hasRelatedWork W1975509879 @default.
• W1975149490 hasRelatedWork W1984265631 @default.

• next