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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975151676> ?p ?o ?g. }

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• W1975151676 abstract "Our objective was to evaluate the levels of miR-210 in tumor and serum samples of conventional renal cell cancer (cRCC) patients to explore whether circulating miR-210 in serum can be used as a biomarker for the detection of cRCC. The paired samples from primary cRCC tumors and adjacent non-tumoral renal parenchyma were collected from 32 patients with cRCC. Serum samples were obtained from 68 patients with a cRCC before surgery, 10 samples after one week of surgery, and 42 healthy individuals were included in this study. Real-time PCR was used to measure the microRNA level. The expression of miRNAs was normalized using the dCT method. Expression levels of miR-210 were compared using the Mann–Whitney U test or Wilcoxon test. Diagnostic performance of serum miR-210 level was calculated by using the receiver operating characteristic (ROC) curve. The average miR-210 level was higher in primary cRCC tissues than in normal tissue (p = 0.004). For serum samples, the average level of miR-210 was significantly higher in cRCC patients than in controls (p < 0.001). The serum miR-210 level yielded an AUC (the areas under the ROC curve) of 0.874 with a sensitivity of 81.0% and a specificity of 79.4%. Furthermore, the average serum level of miR-210 was significantly decreased in the patients one week after the operation (p = 0.001). Serum mi-210 may have a potential as a novel noninvasive biomarker for the detection of cRCC." @default.
• W1975151676 created "2016-06-24" @default.
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• W1975151676 date "2013-02-01" @default.
• W1975151676 modified "2023-10-14" @default.
• W1975151676 title "Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinoma" @default.
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• W1975151676 doi "https://doi.org/10.1016/j.yexmp.2012.10.005" @default.
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