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• W1975157046 abstract "SYNOPSIS. The sensitive dansyl procedure was used to detect putrescine and spermidine, but not spermine and cadaverine, in pleomorphic Trypanosoma brucei. The polyamines were synthesized in vitro from [3H]ornithine, [14C]arginine and [14C]methionine. Proline, agmatine, and citrulline, but not glutamine, glutamic or pyroglutamic acids, stimulated spermidine formation from [14C]methionine. Putrescine and spermidine synthesis occurred rapidly from ornithine: putrescine synthesis peaked in 0.5 h, spermidine in 1 h. Trypanosoma brucei assimilated exogenous 14C-labeled putrescine, spermidine, and spermine; spermidine and spermine were taken up 5 times as rapidly as putrescine. Polyamine syntheses may therefore be a practical target for novel trypanocies." @default.
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• W1975157046 date "1979-08-01" @default.
• W1975157046 modified "2023-09-26" @default.
• W1975157046 title "Synthesis and Content of Polyamines in BloodstreamTrypanosoma brucei*" @default.
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• W1975157046 doi "https://doi.org/10.1111/j.1550-7408.1979.tb04658.x" @default.
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