FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975165216> ?p ?o ?g. }

• W1975165216 endingPage "835" @default.
• W1975165216 startingPage "829" @default.
• W1975165216 abstract "Abstract This work describes a magnetic separation‐based approach using polymyxin B‐functionalized metal alloy nanomagnets for the rapid elimination of endotoxins from human blood in vitro and functional assays to evaluate the biological relevance of the blood purification process. Playing a central role in gram‐negative sepsis, bacteria‐derived endotoxins are attractive therapeutic targets. However, both direct endotoxin detection in and removal from protein‐rich fluids remains challenging. We present the synthesis and functionalization of ultra‐magnetic cobalt/iron alloy nanoparticles and a magnetic separation‐based approach using polymyxin B‐functionalized nanomagnets to remove endotoxin from human blood in vitro . Conventional chromogenic Limulus Amebocyte Lysate assays confirm decreased endotoxin activity in purified compared to untreated samples. Functional assays assessing key steps in host defense against bacteria show an attenuated inflammatory mediator expression from human primary endothelial cells in response to purified blood samples compared to untreated blood and less chemotactic activity. Exposing Escherichia coli ‐positive blood samples to polymyxin B‐functionalized nanomagnets even impairs the ability of gram‐negative bacteria to form colony forming units, thus making magnetic separation based blood purification a promising new approach for future sepsis treatment." @default.
• W1975165216 created "2016-06-24" @default.
• W1975165216 creator A5008576931 @default.
• W1975165216 creator A5017647895 @default.
• W1975165216 creator A5018301737 @default.
• W1975165216 creator A5032145937 @default.
• W1975165216 creator A5039570122 @default.
• W1975165216 creator A5044094950 @default.
• W1975165216 creator A5065608381 @default.
• W1975165216 creator A5090807930 @default.
• W1975165216 date "2012-12-06" @default.
• W1975165216 modified "2023-10-02" @default.
• W1975165216 title "Endotoxin Removal by Magnetic Separation‐Based Blood Purification" @default.
• W1975165216 cites W1505696422 @default.
• W1975165216 cites W1560040722 @default.
• W1975165216 cites W1965699049 @default.
• W1975165216 cites W1967916767 @default.
• W1975165216 cites W1968334024 @default.
• W1975165216 cites W1969665962 @default.
• W1975165216 cites W1977905350 @default.
• W1975165216 cites W1980045113 @default.
• W1975165216 cites W1985903451 @default.
• W1975165216 cites W1994606929 @default.
• W1975165216 cites W1995707906 @default.
• W1975165216 cites W1996541643 @default.
• W1975165216 cites W1996643996 @default.
• W1975165216 cites W1999876918 @default.
• W1975165216 cites W2001061690 @default.
• W1975165216 cites W2008197106 @default.
• W1975165216 cites W2029172413 @default.
• W1975165216 cites W2032262330 @default.
• W1975165216 cites W2073649346 @default.
• W1975165216 cites W2077819199 @default.
• W1975165216 cites W2079079334 @default.
• W1975165216 cites W2115750472 @default.
• W1975165216 cites W2123593234 @default.
• W1975165216 cites W2134787311 @default.
• W1975165216 cites W2140531400 @default.
• W1975165216 cites W2150799620 @default.
• W1975165216 cites W2155470233 @default.
• W1975165216 cites W2158414689 @default.
• W1975165216 doi "https://doi.org/10.1002/adhm.201200358" @default.
• W1975165216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23225582" @default.
• W1975165216 hasPublicationYear "2012" @default.
• W1975165216 type Work @default.
• W1975165216 sameAs 1975165216 @default.
• W1975165216 citedByCount "43" @default.
• W1975165216 countsByYear W19751652162013 @default.
• W1975165216 countsByYear W19751652162014 @default.
• W1975165216 countsByYear W19751652162015 @default.
• W1975165216 countsByYear W19751652162016 @default.
• W1975165216 countsByYear W19751652162017 @default.
• W1975165216 countsByYear W19751652162018 @default.
• W1975165216 countsByYear W19751652162019 @default.
• W1975165216 countsByYear W19751652162020 @default.
• W1975165216 countsByYear W19751652162021 @default.
• W1975165216 countsByYear W19751652162022 @default.
• W1975165216 countsByYear W19751652162023 @default.
• W1975165216 crossrefType "journal-article" @default.
• W1975165216 hasAuthorship W1975165216A5008576931 @default.
• W1975165216 hasAuthorship W1975165216A5017647895 @default.
• W1975165216 hasAuthorship W1975165216A5018301737 @default.
• W1975165216 hasAuthorship W1975165216A5032145937 @default.
• W1975165216 hasAuthorship W1975165216A5039570122 @default.
• W1975165216 hasAuthorship W1975165216A5044094950 @default.
• W1975165216 hasAuthorship W1975165216A5065608381 @default.
• W1975165216 hasAuthorship W1975165216A5090807930 @default.
• W1975165216 hasConcept C1621761 @default.
• W1975165216 hasConcept C185592680 @default.
• W1975165216 hasConcept C192562407 @default.
• W1975165216 hasConcept C202751555 @default.
• W1975165216 hasConcept C203014093 @default.
• W1975165216 hasConcept C2776040547 @default.
• W1975165216 hasConcept C2778384902 @default.
• W1975165216 hasConcept C2778754761 @default.
• W1975165216 hasConcept C2780026444 @default.
• W1975165216 hasConcept C2781053203 @default.
• W1975165216 hasConcept C43617362 @default.
• W1975165216 hasConcept C501593827 @default.
• W1975165216 hasConcept C523546767 @default.
• W1975165216 hasConcept C54355233 @default.
• W1975165216 hasConcept C55493867 @default.
• W1975165216 hasConcept C57409179 @default.
• W1975165216 hasConcept C86803240 @default.
• W1975165216 hasConcept C89423630 @default.
• W1975165216 hasConceptScore W1975165216C1621761 @default.
• W1975165216 hasConceptScore W1975165216C185592680 @default.
• W1975165216 hasConceptScore W1975165216C192562407 @default.
• W1975165216 hasConceptScore W1975165216C202751555 @default.
• W1975165216 hasConceptScore W1975165216C203014093 @default.
• W1975165216 hasConceptScore W1975165216C2776040547 @default.
• W1975165216 hasConceptScore W1975165216C2778384902 @default.
• W1975165216 hasConceptScore W1975165216C2778754761 @default.
• W1975165216 hasConceptScore W1975165216C2780026444 @default.
• W1975165216 hasConceptScore W1975165216C2781053203 @default.
• W1975165216 hasConceptScore W1975165216C43617362 @default.
• W1975165216 hasConceptScore W1975165216C501593827 @default.
• W1975165216 hasConceptScore W1975165216C523546767 @default.

• next