Matches in SemOpenAlex for { <https://semopenalex.org/work/W1975166251> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1975166251 abstract "Low renin hypertension (LRH), which accounts for 10-20% of patients with idiopathic essential hypertension, bears hormonal similarities to mineralocorticoid-induced hypertension, but elevated mineralocorticoid concentrations have not been found. Some patients with LRH have normal, rather than suppressed, plasma aldosterone concentrations, so that the ratio of aldosterone concentration to PRA (Aldo/PRA) is high, suggesting inappropriately increased aldosterone biosynthesis. We characterized the CYP11B2 gene that encodes the aldosterone synthase, P450c11AS, in hypertensive and control populations in a single clinic in Santiago, Chile. We directly sequenced the entire CYP11B2 gene in 12 patients with LRH, 2 high renin hypertensive controls, and 2 normotensive controls. All sequences were identical, except that 8 of 24 LRH alleles encoded arginine rather than lysine at position 173. The Arg173 and Lys173 variants were expressed in transfected MA-10 cells, and their ability to convert deoxycorticosterone to aldosterone was measured; the apparent Michaelis constant (Km) for Lys173 was 2.73 mumol/L; the Km for Arg173 was 2.53 mumol/L. The apparent maximal velocity (Vmax) for Lys173 was 6.5 x 10(-3) micrograms/mL.24 h; the Vmax for Arg173 was 7.8 x 10(-3) micrograms/mL.24 h. The first order rate constant, Vmax/Km was 2.38 for Lys173 and 3.08 for Arg173. As these values were not significantly different, we sought to determine whether Arg173 is a polymorphism linked to LRH. We examined position 173 in 52 unselected patients with idiopathic hypertension and 55 normotensive controls by PCR amplification of CYP11B2 exons 3-5 followed by digestion with Bsu361, which digests the Arg173 sequence, but not the Lys173 sequence. More of the hypertensive alleles (39 of 104, 37.5%) than normotensive alleles (25 of 110, 22.5%) carried Arg173 (chi 2 = 5.57; P < 0.02). Most of the Arg173 alleles (31 of 72, 43.1%) were from hypertensive patients with Aldo/PRA below 30, whereas only 5 of 24 (20.8%) Arg173 alleles were found in patients with Aldo/PRA greater than 30 (chi 2 = 3.79; P = 0.05) Thus, the ARg173 variant of CYP11B2 may be linked to LRH in Chilean patients." @default.
- W1975166251 created "2016-06-24" @default.
- W1975166251 creator A5005069528 @default.
- W1975166251 creator A5025453236 @default.
- W1975166251 creator A5039353472 @default.
- W1975166251 creator A5064116442 @default.
- W1975166251 creator A5064575852 @default.
- W1975166251 creator A5075375521 @default.
- W1975166251 creator A5082744879 @default.
- W1975166251 creator A5089090807 @default.
- W1975166251 date "1996-12-01" @default.
- W1975166251 modified "2023-09-27" @default.
- W1975166251 title "Genetic variation in P450c11AS in Chilean patients with low renin hypertension." @default.
- W1975166251 cites W1482432683 @default.
- W1975166251 cites W1518176291 @default.
- W1975166251 cites W1974618465 @default.
- W1975166251 cites W1985858914 @default.
- W1975166251 cites W1990953561 @default.
- W1975166251 cites W1995810012 @default.
- W1975166251 cites W2009364340 @default.
- W1975166251 cites W2030621682 @default.
- W1975166251 cites W2070818730 @default.
- W1975166251 cites W2092852891 @default.
- W1975166251 cites W2101338072 @default.
- W1975166251 cites W2135213898 @default.
- W1975166251 cites W2141659719 @default.
- W1975166251 cites W2157821159 @default.
- W1975166251 cites W2399209007 @default.
- W1975166251 cites W25157514 @default.
- W1975166251 doi "https://doi.org/10.1210/jcem.81.12.8954040" @default.
- W1975166251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8954040" @default.
- W1975166251 hasPublicationYear "1996" @default.
- W1975166251 type Work @default.
- W1975166251 sameAs 1975166251 @default.
- W1975166251 citedByCount "20" @default.
- W1975166251 countsByYear W19751662512013 @default.
- W1975166251 countsByYear W19751662512019 @default.
- W1975166251 countsByYear W19751662512020 @default.
- W1975166251 crossrefType "journal-article" @default.
- W1975166251 hasAuthorship W1975166251A5005069528 @default.
- W1975166251 hasAuthorship W1975166251A5025453236 @default.
- W1975166251 hasAuthorship W1975166251A5039353472 @default.
- W1975166251 hasAuthorship W1975166251A5064116442 @default.
- W1975166251 hasAuthorship W1975166251A5064575852 @default.
- W1975166251 hasAuthorship W1975166251A5075375521 @default.
- W1975166251 hasAuthorship W1975166251A5082744879 @default.
- W1975166251 hasAuthorship W1975166251A5089090807 @default.
- W1975166251 hasBestOaLocation W19751662511 @default.
- W1975166251 hasConcept C104317684 @default.
- W1975166251 hasConcept C126322002 @default.
- W1975166251 hasConcept C134018914 @default.
- W1975166251 hasConcept C138976137 @default.
- W1975166251 hasConcept C180754005 @default.
- W1975166251 hasConcept C185592680 @default.
- W1975166251 hasConcept C198710026 @default.
- W1975166251 hasConcept C2776069600 @default.
- W1975166251 hasConcept C2777097880 @default.
- W1975166251 hasConcept C2778525890 @default.
- W1975166251 hasConcept C2780249997 @default.
- W1975166251 hasConcept C54355233 @default.
- W1975166251 hasConcept C71315377 @default.
- W1975166251 hasConcept C71924100 @default.
- W1975166251 hasConcept C84393581 @default.
- W1975166251 hasConcept C86803240 @default.
- W1975166251 hasConceptScore W1975166251C104317684 @default.
- W1975166251 hasConceptScore W1975166251C126322002 @default.
- W1975166251 hasConceptScore W1975166251C134018914 @default.
- W1975166251 hasConceptScore W1975166251C138976137 @default.
- W1975166251 hasConceptScore W1975166251C180754005 @default.
- W1975166251 hasConceptScore W1975166251C185592680 @default.
- W1975166251 hasConceptScore W1975166251C198710026 @default.
- W1975166251 hasConceptScore W1975166251C2776069600 @default.
- W1975166251 hasConceptScore W1975166251C2777097880 @default.
- W1975166251 hasConceptScore W1975166251C2778525890 @default.
- W1975166251 hasConceptScore W1975166251C2780249997 @default.
- W1975166251 hasConceptScore W1975166251C54355233 @default.
- W1975166251 hasConceptScore W1975166251C71315377 @default.
- W1975166251 hasConceptScore W1975166251C71924100 @default.
- W1975166251 hasConceptScore W1975166251C84393581 @default.
- W1975166251 hasConceptScore W1975166251C86803240 @default.
- W1975166251 hasLocation W19751662511 @default.
- W1975166251 hasLocation W19751662512 @default.
- W1975166251 hasOpenAccess W1975166251 @default.
- W1975166251 hasPrimaryLocation W19751662511 @default.
- W1975166251 hasRelatedWork W171661703 @default.
- W1975166251 hasRelatedWork W1975166251 @default.
- W1975166251 hasRelatedWork W1980328605 @default.
- W1975166251 hasRelatedWork W2031245924 @default.
- W1975166251 hasRelatedWork W2058444715 @default.
- W1975166251 hasRelatedWork W2061698018 @default.
- W1975166251 hasRelatedWork W2098220178 @default.
- W1975166251 hasRelatedWork W2099735579 @default.
- W1975166251 hasRelatedWork W2253767198 @default.
- W1975166251 hasRelatedWork W2892639011 @default.
- W1975166251 isParatext "false" @default.
- W1975166251 isRetracted "false" @default.
- W1975166251 magId "1975166251" @default.
- W1975166251 workType "article" @default.